Results 151 to 160 of about 82,953 (296)

Arginine Methylation of STAT1 [PDF]

Cell, 2004
Meissner, Torsten, Krause, Eberhard, Lödige, Inga, Vinkemeier, Uwe   +3 more
openaire   +1 more source

STAT1 drives M1 macrophage polarization during Aspergillus fumigatus infection

European Journal of Medical Research
Background Macrophages exhibit distinct polarization states (M1/M2) in response to inflammatory stimuli. However, the molecular mechanisms regulating macrophage polarization during Aspergillus fumigatus infection remain incompletely understood. Objective
Wenjun Wang, Jiannan Liu, Jian Xu, Yi Shi   +3 more
doaj   +1 more source

Changes of P-Tyr-STAT1 and STAT1 expression after KGF treatment in LoVo cells.

, 2013
Increased expression of P-Tyr-STAT1, but not STAT1, were confirmed by western blot in LoVo cells with KGF (150 ng/ml) treatment. Tubulin was used as internal control.
Hua Yang (120668), Wen-Sheng Wang (388411), Daniel H. Teitelbaum (307655), Yu-Jiao Cai (388410), Li-Hua Sun (388412), Yang Yang (45629)   +5 more
core   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, Accepted Article.
Objectives To elucidate role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1KO and β‐TrCP2KO mice, along with myeloid‐specific conditional β‐TrCP2KO (β‐TrCP2ΔM) mice.
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

A Computed Tomography Radiomics Approach for Assessing the T Cell‐Inflamed Gene Expression Profile in Hepatocellular Carcinoma and Its Association With Immunotherapy Response

Health Care Science, EarlyView.
The T cell‐inflamed gene expression profile (GEP) provides a biomarker for immunotherapy response across various cancers. We established a CT‐based radiomics model to predict the T cell‐inflamed GEP and immunotherapy response in hepatocellular carcinoma (HCC).
Mimi Tang, Kaiyu Sun, Dasheng Wu, Yujian Zou, Jian Zhou, Bin Li, Huanjing Hu, Zhenpeng Peng, Jifei Wang, Bingsheng Huang, Shi‐Ting Feng, Shuling Chen   +11 more
wiley   +1 more source