Results 171 to 180 of about 112,289 (303)

STAT1 Para-Naso-Plastic Syndrome [PDF]

C68. THORACIC ONCOLOGY CASE REPORTS II, 2020
C. Kloefkorn, J. Thompson, T.L. Dotson, J. Caldwell, L. Cristiano, K.W. Thomas   +5 more
openaire   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy. [PDF]

Cell Death Dis
Chen JY, Xue YT, Lin B, Huang XY, Lin F, Chen DN, Zhang WJ, Wei Y, Xue XY, Zheng QS, Ke ZB, Xu N.   +11 more
europepmc   +1 more source

Decoding immune‐driven erythroid failure in pure red cell aplasia

British Journal of Haematology, EarlyView.
Pure red cell aplasia (PRCA) is increasingly recognised as a T‐cell‐mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T‐cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer ...
Federico Spataro, Vanessa Desantis, Antonio Giovanni Solimando   +2 more
wiley   +1 more source

Porphyromonas gingivalis Suppresses Interferon-Gamma Signaling in Macrophages Through a Contact-Dependent, Gingipain-Mediated Mechanism. [PDF]

Microbiologyopen
Abe S, Ohshima J, Morita M, Tanaka N, Hayashi M.   +4 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment. [PDF]

Cell Death Discov
He W, Zheng L, Huang W, Li K, Chen Y, Zeng R, Lin Z, Xu Y, Hu S, Zhang Q.   +9 more
europepmc   +1 more source

Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy

Cancer Science, EarlyView.
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen, Qian Tang, Xiqian Chen, Yinghao Liang, Jin Qiu, Yongmei Liao, Changqiang Li, Hongru Yu, Fang Xie, Zongjunlin Liu   +9 more
wiley   +1 more source

Identifying the therapeutic potential of niclosamide in overcoming IFN-gamma dependent cancer immune evasion in the tumor microenvironment. [PDF]

Front Immunol
Zhang Y, Cai E.
europepmc   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, EarlyView.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source