Results 191 to 200 of about 82,953 (296)

Differential regulation of basal and interferon-induced <i>APOL1</i> gene expression in podocytes. [PDF]

Am J Physiol Renal Physiol
Huang C, Wu Z, Bartolomeo KR, O'Toole JF, Sedor JR, Bruggeman LA.   +5 more
europepmc   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

HEATR1 deficiency enhanced gastric cancer cell PANoptosis to boost anti-tumor immunity. [PDF]

Mol Med
Huang Y, Xu Q, Zhu M, Shen Y, Zhang X.
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation. [PDF]

Genes Dev
López-Palacios TP, Madhusanka D, Scott SM, Vaughan AJ, Egbert CM, Chan TY, Bustos Y, Ashworth SW, Truman JM, Per Moreno A, Tsang TM, Jayatunge DN, Yang J, Nelson P, Al-Sudani F, Tarara M, Kohler E, Pereira Mendiola NE, Soderblom EJ, Stubben CJ, Stewart PA, Kolasangiani R, Dobish KK, Knobel B, Buckley SM, Bidone TC, Smoot RL, Uchida AM, Morawe M, Armacki M, Andersen JL.   +30 more
europepmc   +1 more source

Wild-type C9orf72 drives proteasomal dysfunction and mutant aggregates via a Stat1-Isg15 axis in Huntington's disease. [PDF]

Neurotherapeutics
Chan SC, Tung CW, Chang CY, Su CC, Chen YC, Wu PM, Tung CY, Chen SF, Kuo HY, Cheng PH, Chen CM, Yang SH.   +11 more
europepmc   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

Anellovirus-mediated interferon dysregulation enhances virus-induced lung injury. [PDF]

Am J Respir Cell Mol Biol
Banday MM, Banday S, Rahman M, Harrison AO, Singh N, Moore RM, Khan MM, Shankar S, Goda Y, Coppolino A, Movval N, Stutts S, Woolley A, Dishaw L, Goldberg H, Mebratu Y, Polson SW, Patel KN, Gaggar A, Hayes D, Krishnamoorthy N, Gewurz BE, Washko G, Tesfaigzi Y, Rehman R, Sharma NS.   +25 more
europepmc   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source