Results 201 to 210 of about 82,953 (296)

Predicted <i>STAT1</i>-<i>BRAF</i> and <i>IRF7</i>-<i>MET</i> Regulatory Links Are Associated with MAPK Pathway Reactivation and Targeted Therapy Resistance in Melanoma. [PDF]

Int J Mol Sci
Fu H, Wang M, Zhu H, Li W, Shen X, Yan H, He J.   +6 more
europepmc   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Astragalus polysaccharide antagonized anti PD-1 efficacy in melanoma through inhibiting JAK-STAT1/CIITA and TLR/NF-κB signaling. [PDF]

Front Immunol
Wang R, Li Q, Liu M, Yu J, Peng M, Deng X, Lei R, Liu X, Li Z, Leong H, Ren J, Wu J.   +11 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

STAT1 gain-of-function in 12 Moroccan patients: Clinical and genetic insights. [PDF]

J Hum Immun
Baghad B, Benhsaien I, El Fatoiki FZ, Ouair H, Moundir A, Errami A, Soussi-Abdellaoui M, Migaud M, Casanova JL, Puel A, El Bakkouri J, Bousfiha AA, Chiheb S, Ailal F.   +13 more
europepmc   +1 more source

Synergistic interaction between the macrophage polarizing signals IL-4 and IFNγ is controlled by the STAT6/STAT1/IRF1 axis. [PDF]

Nucleic Acids Res
Varga Z, Poscher A, Váradi EA, Cinege G, Izsán A, Erdős E, Benyhe-Kis B, Tihanyi AZ, Tzerpos P, Bene K, Halász L, Gémes N, Neuperger P, Tóth M, Migh E, Póliska S, Szebeni GJ, Walter JE, Dániel B, Csörgő B, Nagy L, Czimmerer Z.   +21 more
europepmc   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation. [PDF]

Front Immunol
Zhang Z, Xu M, Zhang S, Zhang Z, Zhang H, Wang Z, Zhu M, Zhao H.   +7 more
europepmc   +1 more source