Results 221 to 230 of about 82,953 (296)

Nuclear RSK1 mediates interferon-γ-induced proinflammatory activation in human primary macrophages and humanized mice. [PDF]

Sci Adv
Nihira K, Yanagihara Y, Nakamura Y, Chelvanambi S, Halu A, Lee LH, Mojcher A, Higashi H, Yamada I, Qiao J, Mlynarchik AK, Wang J, Decano JL, Aikawa E, Vrbanac V, Singh SA, Aikawa M.   +16 more
europepmc   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

JARID2 inhibition reprograms human hematopoietic progenitor cells to enhance bone marrow transplantation. [PDF]

Blood Adv
Han W, Bjeije H, Celik H, Rettig M, Issa N, Young AL, Li Y, Raj IX, Zhang CR, Krishnan A, Parsons TM, Burkart SC, Arand J, Yang W, Magee JA, Challen GA.   +15 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

A novel stop-loss variant in ISG15 causes C-terminal dysfunction and impairs USP18-mediated negative feedback. [PDF]

Front Immunol
Zhang W, Chen X, Li Y, Yao X, Huang J, Gao Y, Xing W, Lu D, Deng M, Shu Z, Mao H.   +10 more
europepmc   +1 more source

Periodontal Disease and Salivary Gland Dysfunction in Neurofibromatosis Type 1: A Case–Control Study

Oral Diseases, EarlyView.
ABSTRACT Objectives Neurofibromatosis type 1 (NF1) presents with diverse systemic and oral manifestations. The aim of this study was to investigate the periodontal status and salivary alterations in NF1 individuals. Methods A total of 38 individuals with NF1 diagnostic criteria were compared with a control group paired by age and sex.
Eloá Borges Luna, Gustavo de Souza Vieira, Flávia Lima Kleinsorgen Motta, Ana Beatriz Oliveira Gambôa, Analúcia Rampazzo Xavier, Rafaela Elvira Rozza‐de‐Menezes, Karin Soares Cunha   +6 more
wiley   +1 more source

An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1-C3-TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages. [PDF]

J Orthop Translat
Tao L, Jiang W, Huang Y, Fu X, Wang H, Yang H, Li H, Tian Z, Liu D, Wang S, Zhu Y.   +10 more
europepmc   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

Peripheral Nerve Injury Induces an Interferon-Responsive State Centered on Satellite Glial Cells in the DRG That Sustains Neuropathic Pain Through STAT1 and CXCL10 Signaling. [PDF]

Brain Sci
Hu W, Wang F, Niu Z, Liu P, Tian Z, Luo C, Xie R.   +6 more
europepmc   +1 more source