CD8 T Cell Sensing of Type I Interferon Impacts Anergy
European Journal of Immunology, Volume 56, Issue 5, May 2026.Basal IFN‐I acts as a rheostat to fine‐tune CD8 T cell anergy. The presence of IFN‐I induces a less deep anergic state characterised by greater expansion, residual effector function and plasticity. This favours the accumulation of autoreactive T cells that retain the potential to break tolerance rather than undergoing deletion.
Anne S. Haefke +14 more
wiley +1 more source
JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities. [PDF]
Int J Oral SciHuang Z +6 more
europepmc +1 more source
Resveratrol for Cancer Radio‐Sensitization: Ready for Prime Time or Future Perspective
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Resveratrol exerts antioxidant and anti‐inflammatory effects by reducing reactive oxygen species and suppressing NF‐κB and JAK/STAT signaling pathways. It modulates metabolic signaling through AMPK‐dependent inhibition of mTOR, influencing cell survival and inflammatory responses.
Maryam Fallah +7 more
wiley +1 more source
CD38 overexpression drives glioblastoma progression via L1CAM/ICAM1/JAK-STAT-Driven tumor microenvironment rewiring. [PDF]
Transl OncolNorouzi S, Aulakh S.
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source
HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathway. [PDF]
Front ImmunolGu Z +11 more
europepmc +1 more source
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy
Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley +1 more source
MERS-CoV and SARS-CoV-1 proteins inhibit the IFN-α JAK/STAT pathway of epithelial cells, via IFN-λ-induced USP18. [PDF]
Front ImmunolZhang Y, Stevenson NJ.
europepmc +1 more source
Targeting G9a Exerts Pleiotropic Suppression in Triple-Negative Breast Cancer Cells: Cooperatively Inducing Pyroptosis and Apoptosis. [PDF]
BiomoleculesLi J, Zhang G, Liu T, Yan X, Ma M.
europepmc +1 more source
Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies
MedComm, Volume 7, Issue 5, May 2026.The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He +9 more
wiley +1 more source