Results 261 to 270 of about 112,289 (303)

Phase II Trial of Interleukin-12 Followed by Interferon Alfa-2b in Patients with Metastatic Malignant Melanoma: Results from CALGB 500001 (Alliance). [PDF]

Cancer Immunol Res
Liu A, Johnson C, Niedzwiecki D, Relation T, Yarlagadda SV, Gajewski TF, Carson WE.   +6 more
europepmc   +1 more source

Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression. [PDF]

Cancer Biol Med
Lv Z, Wang T, Fan R, Ming Q, Liu J, Jia Y, Zhang Y, Chen M, Chen W, Jiang Z, Han W, Mei Q.   +11 more
europepmc   +1 more source

Signal Transducers and Activators of Transcription 1 (STAT1), STAT2, and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis. [PDF]

J Infect Dis
Moley CR, Abushahba MFN, Ponzilacqua-Silva B, Kochetkova I, Jackson CD, Skyberg JA.   +5 more
europepmc   +1 more source

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Inborn errors of STAT1 immunity

Current Opinion in Immunology, 2021
Signal transducer and activator of transcription 1 (STAT1) is a latent cytoplasmic transcription factor that is activated by multiple stimuli, including type I, II, and III interferons and interleukin-27. Inborn errors of human STAT1 immunity underlie 4 distinct disorders: autosomal recessive (AR) complete STAT1 deficiency, AR partial STAT1 deficiency,
Yoko, Mizoguchi, Satoshi, Okada
openaire   +2 more sources

Optineurin regulates osteoblastogenesis through STAT1

Biochemical and Biophysical Research Communications, 2020
A sophisticated and delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts regulates bone metabolism. Optineurin (OPTN) is a gene involved in primary open-angle glaucoma and amyotrophic lateral sclerosis. Although its function has been widely studied in ophthalmology and neurology, recent reports have shown its ...
Noriyoshi Mizuno, Tomoyuki Iwata, Ryosuke Ohsawa, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Yukiko Matsuda, Kodai Kume, Yui Tada, Hiroyuki Morino, Tetsuya Yoshimoto, Yasuyoshi Ueki, Keichiro Mihara, Yusuke Sotomaru, Katsuhiro Takeda, Syuichi Munenaga, Tsuyoshi Fujita, Hiroyuki Kawaguchi, Hideki Shiba, Hideshi Kawakami, Hidemi Kurihara   +20 more
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Stat1-mediated cytoplasmic attenuation in osteoimmunology

Journal of Cellular Biochemistry, 2005
Signal transducer and activator of transcription 1 (Stat1) is a critical mediator of gene transcription in type I interferon (IFN-alpha/beta) signaling that is essential for host defense against viruses. In the skeletal system, type I IFNs (IFN-alpha/beta) also play an important physiological role in the inhibition of receptor activator of NF-kappaB ...
Hiroshi, Takayanagi, Sunhwa, Kim, Takako, Koga, Tadatsugu, Taniguchi   +3 more
openaire   +2 more sources

CITED2 inhibits STAT1‐IRF1 signaling and atherogenesis

The FASEB Journal, 2021
Abstract Macrophages are the principal component of the innate immune system. They play very crucial and multifaceted roles in the pathogenesis of inflammatory vascular diseases. There is an increasing recognition that transcriptionally dynamic macrophages are the key players in the pathogenesis of inflammatory ...
Atif Zafar, Hang Pong Ng, Rachel Diamond‐Zaluski, Gun‐Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar   +7 more
openaire   +2 more sources

STAT1 gene expression in cervical carcinomas

Biochemistry (Moscow), 2007
Expression of the STAT1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (HPV) of so-called high risk group. Expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent ...
G V, Volgareva, D A, Golovina, N M, Gasparjan, V D, Ermilova, L S, Pavlova, A A, Petrenko, M N, Fedorova, L K, Kurbatov, I B, Cheglakov, K N, Jarigin, F L, Kisseljov   +10 more
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Bcl6 promotes osteoblastogenesis through Stat1 inhibition

Biochemical and Biophysical Research Communications, 2015
Bone mass is tightly controlled by a balance between osteoclast and osteoblast activities. Although these cell types mature via different pathways, some factors reportedly regulate differentiation of both. Here, in a search for factors governing osteoblastogenesis but also expressed in osteoclasts to control both cell types by one molecule, we ...
Atsuhiro Fujie, Atsushi Funayama, Yoshiteru Miyauchi, Yuiko Sato, Tami Kobayashi, Hiroya Kanagawa, Eri Katsuyama, Wu Hao, Toshimi Tando, Ryuichi Watanabe, Mayu Morita, Kana Miyamoto, Arihiko Kanaji, Hideo Morioka, Morio Matsumoto, Yoshiaki Toyama, Takeshi Miyamoto   +16 more
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STAT1: A many-sided transcription factor

Russian Journal of Bioorganic Chemistry, 2010
Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling systems is the STAT family, which is comprised of seven members.
I A, Kostanian, A V, Vonarshenko, V M, Lipkin   +2 more
openaire   +2 more sources