Results 261 to 270 of about 82,953 (296)

STAT1 as a key modulator of cell death

Cellular Signalling, 2007
Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that mediate various biological responses, including cell proliferation, survival, apoptosis, and differentiation. Among the members of the STAT family, accumulating evidence now indicates an important role for STAT1 in various forms of cell death ...
Myung-Shik Lee, Hun Sik Kim
exaly   +3 more sources

STAT1 gene expression in cervical carcinomas

Biochemistry (Moscow), 2007
Expression of the STAT1 gene belonging to the group of interferon-regulated genes was analyzed in cervical tumors and cell lines harboring the genome of human papilloma viruses (HPV) of so-called high risk group. Expression of this gene in invasive carcinomas was maintained on a definite level that was not significantly distinct from that in adjacent ...
G V, Volgareva, D A, Golovina, N M, Gasparjan, V D, Ermilova, L S, Pavlova, A A, Petrenko, M N, Fedorova, L K, Kurbatov, I B, Cheglakov, K N, Jarigin, F L, Kisseljov   +10 more
openaire   +2 more sources

Stat1-mediated cytoplasmic attenuation in osteoimmunology

Journal of Cellular Biochemistry, 2005
Signal transducer and activator of transcription 1 (Stat1) is a critical mediator of gene transcription in type I interferon (IFN-alpha/beta) signaling that is essential for host defense against viruses. In the skeletal system, type I IFNs (IFN-alpha/beta) also play an important physiological role in the inhibition of receptor activator of NF-kappaB ...
Hiroshi, Takayanagi, Sunhwa, Kim, Takako, Koga, Tadatsugu, Taniguchi   +3 more
openaire   +2 more sources

Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma

Cellular Signalling
The signal transducer and activator of transcription 1 (STAT1) plays a crucial role in regulating tumor progression. However, the mechanisms governing its phosphorylation and biological functions remain incompletely understood. Here, we present compelling evidence indicating that knockdown of SIRT7 inhibits Smurf1-induced ubiquitination of STAT1 ...
Ling, Dong, Xufu, Wei, Le, Yu, Yixin, Li, Lixue, Chen   +4 more
openaire   +2 more sources

The role of Stat1 serine phosphorylation in Stat1 transcriptional activity

2011
Interferons (IFNs) regulate immune responses upon viral and bacterial infections by triggering the JAK/Stat signaling pathway. In these signaling responses, signal transducers and activators of transcription (Stats) become tyrosine phosphorylated, translocate into the nucleus, bind to DNA and activate transcription of individual target genes.
openaire   +1 more source

Optineurin regulates osteoblastogenesis through STAT1

Biochemical and Biophysical Research Communications, 2020
A sophisticated and delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts regulates bone metabolism. Optineurin (OPTN) is a gene involved in primary open-angle glaucoma and amyotrophic lateral sclerosis. Although its function has been widely studied in ophthalmology and neurology, recent reports have shown its ...
Noriyoshi Mizuno, Tomoyuki Iwata, Ryosuke Ohsawa, Kazuhisa Ouhara, Shinji Matsuda, Mikihito Kajiya, Yukiko Matsuda, Kodai Kume, Yui Tada, Hiroyuki Morino, Tetsuya Yoshimoto, Yasuyoshi Ueki, Keichiro Mihara, Yusuke Sotomaru, Katsuhiro Takeda, Syuichi Munenaga, Tsuyoshi Fujita, Hiroyuki Kawaguchi, Hideki Shiba, Hideshi Kawakami, Hidemi Kurihara   +20 more
openaire   +3 more sources

STAT1: A many-sided transcription factor

Russian Journal of Bioorganic Chemistry, 2010
Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling systems is the STAT family, which is comprised of seven members.
I A, Kostanian, A V, Vonarshenko, V M, Lipkin   +2 more
openaire   +2 more sources

Cloning and developmental expression of Xenopus Stat1

Developmental & Comparative Immunology, 2001
Proteins of the STAT family (Signal Transducers and Activators of Transcription) are latent cytoplasmic factors which, upon phosphorylation, are translocated to the nucleus where they participate in gene activation. In this report, we describe the cloning and developmental expression of a Xenopus homolog of Stat1. XStat1 is highly conserved, exhibiting
J B, Turpen, D L, Carlson, C, Huang
openaire   +2 more sources

The Ins and Outs of STAT1 Nuclear Transport

Science's STKE, 2003
There is an inherent elegance in being in the right place at the right time. The STAT1 transcription factor possesses regulatory signals that ensure its distribution to the right cellular location at the right time. Latent STAT1 resides primarily in the cytoplasm, and there it responds to hormone signaling through tyrosine phosphorylation by Janus ...
Kevin M, McBride, Nancy C, Reich
openaire   +2 more sources

Increased STAT1 Amounts Correlate with the Phospho-STAT1 Level in STAT1 Gain-of-function Defects

Journal of Clinical Immunology, 2018
Andrea R, Bernasconi, Judith, Yancoski, Mariana, Villa, Matías M, Oleastro, Miguel, Galicchio, Jorge G, Rossi   +5 more
openaire   +2 more sources