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Cellular Signalling
The signal transducer and activator of transcription 1 (STAT1) plays a crucial role in regulating tumor progression. However, the mechanisms governing its phosphorylation and biological functions remain incompletely understood. Here, we present compelling evidence indicating that knockdown of SIRT7 inhibits Smurf1-induced ubiquitination of STAT1 ...
Ling, Dong +4 more
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The signal transducer and activator of transcription 1 (STAT1) plays a crucial role in regulating tumor progression. However, the mechanisms governing its phosphorylation and biological functions remain incompletely understood. Here, we present compelling evidence indicating that knockdown of SIRT7 inhibits Smurf1-induced ubiquitination of STAT1 ...
Ling, Dong +4 more
openaire +2 more sources
The role of Stat1 serine phosphorylation in Stat1 transcriptional activity
2011Interferons (IFNs) regulate immune responses upon viral and bacterial infections by triggering the JAK/Stat signaling pathway. In these signaling responses, signal transducers and activators of transcription (Stats) become tyrosine phosphorylated, translocate into the nucleus, bind to DNA and activate transcription of individual target genes.
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Cloning and developmental expression of Xenopus Stat1
Developmental & Comparative Immunology, 2001Proteins of the STAT family (Signal Transducers and Activators of Transcription) are latent cytoplasmic factors which, upon phosphorylation, are translocated to the nucleus where they participate in gene activation. In this report, we describe the cloning and developmental expression of a Xenopus homolog of Stat1. XStat1 is highly conserved, exhibiting
J B, Turpen, D L, Carlson, C, Huang
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STAT1 and herpesviruses: Making lemonade from lemons
VirologySignal transducer and activator of transcription 1 (STAT1) is engaged downstream of interferon and other cytokine receptors and has traditionally been defined as an antiviral effector of the host. Consistent with the antiviral role, genetic deficiency of STAT1 leads to increased replication of diverse viruses and severe disease that can lead to host's ...
Erika R, Johansen, Vera L, Tarakanova
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Increased STAT1 Amounts Correlate with the Phospho-STAT1 Level in STAT1 Gain-of-function Defects
Journal of Clinical Immunology, 2018Andrea R, Bernasconi +5 more
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STAT1 and MHCII: guardians of stressed HSCs
Blood, 2022Sebastian Kollmann, Veronika Sexl
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