R788 is Associated with Neuroprotective Effects in Experimental Ischemic Stroke Models via Modulation of the STAT1/Nrf2/GPX4 Axis. [PDF]
Yang Y +5 more
europepmc +1 more source
A reproducible epithelial transcriptional state combines interferon-associated and secretory programs in pancreatic ductal adenocarcinoma. [PDF]
Mi X, Wu S, Xiao L.
europepmc +1 more source
HIV-1 Nef inhibits the JAK/STAT signaling pathway by inducing proteasomal degradation of STAT1. [PDF]
Rodrigues RL +11 more
europepmc +1 more source
USP9X trims STAT1 to curb oncostatin M activity and intestinal inflammation. [PDF]
Hegazy AN.
europepmc +1 more source
Cobalt-mediated suppression of IFN-γ-JAK-STAT1 signaling reprograms IDO1-driven immunosuppression for metalloimmunotherapy. [PDF]
Jiang T +11 more
europepmc +1 more source
STAT1 and pathogens, not a friendly relationship
International audienceSTAT1 belongs to the STAT family of transcription factors, which comprises seven factors: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT1 is a 91 kDa protein originally identified as the mediator of the cellular response
Rémi Fagard
exaly +5 more sources
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Inborn errors of STAT1 immunity
Current Opinion in Immunology, 2021Signal transducer and activator of transcription 1 (STAT1) is a latent cytoplasmic transcription factor that is activated by multiple stimuli, including type I, II, and III interferons and interleukin-27. Inborn errors of human STAT1 immunity underlie 4 distinct disorders: autosomal recessive (AR) complete STAT1 deficiency, AR partial STAT1 deficiency,
Yoko, Mizoguchi, Satoshi, Okada
openaire +2 more sources
Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma [PDF]
: Interferons (IFNs) with antiviral and immune-stimulatory functions have been widely used in prevention and treatment of hepatocellular carcinoma (HCC).
Pengyu Liu +2 more
exaly +2 more sources

