Results 71 to 80 of about 82,953 (296)
Role of STAT1 in the breast [PDF]
JAK-STAT, 2012 Signal transducer and activator of transcription-1 (STAT1) plays a role in the transduction of stress and cytokine responses, DNA damage, and activation of B and T cell immune responses. The ability of STAT1 to act as a pro- or anti-apoptotic signaling molecule depends upon the cellular environment and stimulus. Post-translational modifications provide
Bailey, SG, Cragg, MS, Townsend, PA
openaire +3 more sources
Frontiers in Bioscience-LandmarkBackground: Retinal pigment epithelial (RPE) cells have a pivotal function in preserving the equilibrium of the retina and moderating the immunological interaction between the choroid and the retina.
Hongjun Zhang +4 more
doaj +1 more source
Journal of Biomedical Science, 2022 Background Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for patients with CRC are still needed. Recently, fluorescent chemical probes have been developed for cancer imaging and therapy. Signal transducer and
Pei-Hsuan Chou +11 more
doaj +1 more source
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
The role of STAT1 in viral sensitization to LPS [PDF]
Journal of Endotoxin Research, 2003 The phenomenon of endotoxin sensitization by virus infection is well documented but not yet well understood. Infection by virtually any viral agent will quickly induce expression of type I interferons (IFN-α/β), and type II IFN-γ production will follow as NK cells and T cells are activated. It has been well established that type II IFN pretreatment can
Joan, Durbin +5 more
openaire +2 more sources
Heterozygosity for the Y701C STAT1 mutation in a multiplex kindred with multifocal osteomyelitis [PDF]
, 2014 Heterozygosity for dominant-negative STAT1 mutations underlies autosomal dominant Mendelian susceptibility to mycobacterial diseases. Mutations conferring Mendelian susceptibility to mycobacterial diseases have been identified in the regions of the STAT1
Hirata, Osamu
core +1 more source
IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis
Advanced Science, EarlyView.The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui +12 more
wiley +1 more source
Bidirectional Impact of Varying Severity of Acute Kidney Injury on Calcium Oxalate Stone Formation
Kidney & Blood Pressure ResearchIntroduction: Acute kidney injury (AKI) is a prevalent renal disorder. The occurrence of AKI may promote the formation of renal calcium oxalate stones by exerting continuous effects on renal tubular epithelial cells (TECs).
Yu Yang +5 more
doaj +1 more source
A time- and dose-dependent STAT1 expression system
BMC Biotechnology, 2006 Background The signal transducer and activator of transcription (STAT) family of transcription factors mediates a variety of cytokine dependent gene regulations.
Painz Ronald +7 more
doaj +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source