Results 51 to 60 of about 112,289 (303)

T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival. [PDF]

PLoS ONE, 2011
STAT1 is an essential part of interferon signaling, and STAT1-deficiency results in heightened susceptibility to infections or autoimmunity in both mice and humans.
Hiroshi Moro, Dennis C Otero, Yoshinari Tanabe, Michael David   +3 more
doaj   +1 more source

STAT1/MUC4 activation promotes antimicrobial peptide production to reduce intestinal epithelium barrier injury caused by enteropathogenic Escherichia coli infection

Archives of Medical Science, 2023
Introduction Antimicrobial peptides (AMPs) are endogenous peptides that have been identified to alleviate intestinal epithelial barrier inflammation and dysfunction caused by enteropathogenic Escherichia coli (EPEC) infection; nonetheless, the upstream ...
Liu Pei, Zhigang Zuo, Meixiang Zhang, Likun Zhao, Kaishuang Li   +4 more
doaj   +1 more source

Acetylation of Stat1 modulates NF-κB activity [PDF]

Genes & Development, 2006
Acetylation of signaling molecules can lead to apoptosis or differentiation of carcinoma cells. The molecular mechanisms underlying these processes and the biological role of enzymes mediating the transfer or removal of an acetyl-group are currently under intense investigation. Our study shows that Stat1 is an acetylated protein.
Krämer, Oliver H., Baus, Daniela, Knauer, Shirley, Stein, Stefan, Jäger, Elke, Stauber, Roland H., Grez, Manuel, Pfitzner, Edith, Heinzel, Thorsten   +8 more
openaire   +3 more sources

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system.
Azad, Abul, D'Costa, Zenobia, Diana, Angela, Dushek, Omer, Fokas, Emmanouil, Jones, Keaton, Kruger, Philipp, Liu, Stanley, McKenna, W. Gillies, Muschel, Ruth J., Sansom, Owen J., Yin Lim, Su   +11 more
core   +1 more source

Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. [PDF]

PLoS ONE, 2008
Inactivation of p27 Kip1 is implicated in tumorigenesis and has both prognostic and treatment-predictive values for many types of human cancer. The transcription factor Stat1 is essential for innate immunity and tumor immunosurveillance through its ...
Shuo Wang, Jennifer F Raven, Joan E Durbin, Antonis E Koromilas   +3 more
doaj   +1 more source

Tuning up STAT1

PLOS Biology, 2015
STAT1 is a key regulator of diverse immune responses, but the basis of this diversity is poorly understood; a new study uses a parasite's ability to block STAT1 to identify the host protein TLX as a modulator of STAT1 activity in the brain. Read the accompanying Research Article.
openaire   +4 more sources

Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry [PDF]

, 2008
We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass ...
Aebersold R., Boyle E. I., Chong P. K., Cottingham K., Cove D. H., Ezeh U. I., Foran E., Gygi S. P., Ioachim E., Jacobs J. M., Keller A., Laemmli U. K., Lapillonne A., Lin C. S., Liu H., Maclean B., Mathelin C., Metodiev M. V., old W. M., Patterson S. D., Pedrioli P. G., Rauch A., Schmidt A., Sealfon R. S., Seo J., Sheen-Cheen S. M., Silva J., Taylor M. R., Toi M., Wolters D. A., Zhang J.   +30 more
core   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Fludarabine Ameliorates Lupus Nephritis by Inhibiting T Cell Infiltration through STAT1 in R848-induced Mice Models

Korean Journal of Clinical Laboratory Science
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj   +1 more source

Epithelial cell–derived secreted and transmembrane 1a signals to activated neutrophils during pneumococcal pneumonia [PDF]

, 2016
Airway epithelial cell responses are critical to the outcome of lung infection. In this study, we aimed to identify unique contributions of epithelial cells during lung infection.
Belkina, Anna C., Deng, Jane C., Gower, Adam C., Jones, Matthew R., Kamata, Hirofumi, Lung, Wing Yi, Mizgerd, Joseph P., Quinton, Lee J., Ramirez, Maria I., Wasserman, Gregory A., Yamamoto, Kazuko, Yuen, Constance K., Zabinski, Mary C.   +12 more
core   +1 more source