Results 51 to 60 of about 82,953 (296)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
STAT1 from the cell membrane to the DNA [PDF]
The EMBO Journal, 2001 The binding of interferons (IFNs) to their receptors leads to the phosphorylation and activation of signal transducers and activators of transcription (STATs), and their translocation from the cytoplasm to the nucleus. The mechanisms by which the STATs move to the nuclear pore are not, however, known.
B F, Lillemeier, M, Köster, I M, Kerr
openaire +2 more sources
Korean Journal of Clinical Laboratory ScienceSystemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Regulation of ULK1 Expression and Autophagy by STAT1 [PDF]
Journal of Biological Chemistry, 2017 Autophagy involves the lysosomal degradation of cytoplasmic contents for regeneration of anabolic substrates during nutritional or inflammatory stress. Its initiation occurs rapidly after inactivation of the protein kinase mammalian target of rapamycin (mTOR) (or mechanistic target of rapamycin), leading to dephosphorylation of Unc-51-like kinase 1 ...
Alexander A, Goldberg +9 more
openaire +2 more sources
Advanced Materials, EarlyView.Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma +15 more
wiley +1 more source
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. [PDF]
PLoS ONE, 2008 Inactivation of p27 Kip1 is implicated in tumorigenesis and has both prognostic and treatment-predictive values for many types of human cancer. The transcription factor Stat1 is essential for innate immunity and tumor immunosurveillance through its ...
Shuo Wang +3 more
doaj +1 more source
PLOS Biology, 2015 STAT1 is a key regulator of diverse immune responses, but the basis of this diversity is poorly understood; a new study uses a parasite's ability to block STAT1 to identify the host protein TLX as a modulator of STAT1 activity in the brain. Read the accompanying Research Article.
openaire +4 more sources
Viral interferon antagonists and antiviral drugs [PDF]
, 2009 For this project, we developed reporter cell lines that express viral proteins with the potential to be used in cell-based screening assays to select chemical candidates for antiviral drugs.
Nobre, Rita
core +2 more sources
Journal of Advanced Biotechnology and Experimental TherapeuticsIFNGR1 and STAT1 are key components of the JAK–STAT pathway mediated by IFN-γ, with potential as important biomarkers for TB. INFGR1 acts as the binding and signal reception site for IFN-γ.
Randi Rimpung +8 more
doaj +1 more source