Results 31 to 40 of about 82,953 (296)

Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo. [PDF]

PLoS ONE, 2014
Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signaling, essential in mediating host defense against viruses and other pathogens.
Nicole R Leitner, Caroline Lassnig, Rita Rom, Susanne Heider, Zsuzsanna Bago-Horvath, Robert Eferl, Simone Müller, Thomas Kolbe, Lukas Kenner, Thomas Rülicke, Birgit Strobl, Mathias Müller   +11 more
doaj   +1 more source

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A., McCormick, J., Latchman, David S., Knight, R,A,, Bourke, L.T.   +4 more
core   +1 more source

Stat1 and SUMO modification

Blood, 2006
Abstract Many proteins are known to undergo small ubiquitin-related modifier (SUMO) modification by an E1-, E2-, and E3-dependent ligation process. Recognition that protein inhibitor of activated signal transducers and activators of transcription (STATs) (PIAS) proteins are SUMO E3 ligases raised the possibility that STATs may also be
Li, Song, Samita, Bhattacharya, Ali A, Yunus, Christopher D, Lima, Christian, Schindler   +4 more
openaire   +3 more sources

Involvement of Stat1 in the Phagocytosis ofM. avium [PDF]

Clinical and Developmental Immunology, 2012
Mycobacterium aviumis an intracellular pathogen preferentially infecting human macrophages where they activate the JAK/STAT1 pathway. This activation enhances the survival of infected cells, but, at the same time, makes macrophages optimal targets for drugs development against p-tyr701stat1.
DOMINICI S, SCHIAVANO, GIUDITTA FIORELLA, MAGNANI, MAURO, BUONDELMONTE C, CELESTE A. G, BRANDI, GIORGIO   +5 more
openaire   +4 more sources

The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes. [PDF]

PLoS ONE, 2015
The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance effects of interferons and ...
Jennifer D Sisler, Magdalena Morgan, Vidisha Raje, Rebecca C Grande, Marta Derecka, Jeremy Meier, Marc Cantwell, Karol Szczepanek, William J Korzun, Edward J Lesnefsky, Thurl E Harris, Colleen M Croniger, Andrew C Larner   +12 more
doaj   +1 more source

Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma [PDF]

, 2015
Background Cancers adapt to immune-surveillance through evasion. Immune responses against carcinoma and melanoma converge on cytotoxic effectors and IFNγ-STAT1-IRF1 signalling. Local IFN-driven immune checkpoint expression can mediate feedback inhibition
Matthew Care (3572957), Tooze, RM, Westhead, DR, David Westhead (3572960), David R. Westhead, Reuben M. Tooze, Care, MA, Reuben Tooze (271067), Matthew A. Care   +8 more
core   +1 more source

Mechanisms of Rejection of High Grade B cell Lymphoma in Mice [PDF]

, 2008
The incidence of high grade B cell lymphoma in western countries has increased over the last decades. Improvement of conventional chemotherapy regimens has significantly contributed to prolonged 5-year survival rates which currently reach around 60 ...
Sukumar, Madhusudhanan
core   +1 more source

JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer

OncoImmunology, 2017
Human pancreatic cancer does not respond to immune check point blockade immunotherapy. One key feature of pancreatic cancer is the association between its progression and chronic inflammation.
Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh, Kebin Liu   +4 more
doaj   +1 more source

PTP1B regulates TLR4-STAT1-iNOS pathway activation.

, 2019
Wild-type and PTP1B-/- bone marrow-derived neutrophils were left untreated (NT) or exposed to P. aeruginosa strain 8821 at a MOI of 10 for 3, 6, 12 and 24 h. (A) Total RNA of 3 h was isolated.
Hua Li (46469), Lei Yue (276252), Tianhong Xie (5828993), Xia Song (594494), Min Yan (119568), Ting Yang (189879), Zhongping Xie (3484469), Tong-Jun Lin (386098), Michel L. Tremblay (166249)   +8 more
core   +1 more source

Distinct Clinical Phenotypes Associated with JAK2V617F Reflect Differential STAT1 Signaling [PDF]

, 2010
SummaryThe JAK2V617F mutation is associated with distinct myeloproliferative neoplasms, including polycythemia vera (PV) and essential thrombocythemia (ET), but it remains unclear how it generates disparate disorders. By comparing clonally-derived mutant
Chen, Edwin, Green, Anthony R., Emmanouil T. Dermitzakis, Campbell, P.J., Edwin Chen, Dermitzakis, E.T., Dermitzakis, Emmanouil T., Anna L. Godfrey, Anthony R. Green, Peter J. Campbell, Juan Li, Chen, E., Ingle, C.E., Green, A.R., Ana P. Costa-Pereira, Beer, P.A., Christina A. Ortmann, Philip A. Beer, Beer, Philip A., Li, Juan, Dermitzakis, Emmanouil, Ingle, Catherine E., Catherine E. Ingle, Ortmann, Christina A., Campbell, Peter J., Godfrey, A.L., Ortmann, C.A., Costa-Pereira, A.P., Li, J., Godfrey, Anna L., Costa-Pereira, Ana P.   +30 more
core   +1 more source