Results 11 to 20 of about 82,953 (296)

STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation [PDF]

Frontiers in Immunology, 2019
Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses.
Ofer Zimmerman, Peter Olbrich, Peter Olbrich, Alexandra F. Freeman, Lindsey B. Rosen, Gulbu Uzel, Christa S. Zerbe, Sergio D. Rosenzweig, Hye Sun Kuehn, Kevin L. Holmes, David Stephany, Li Ding, Elizabeth P. Sampaio, Amy P. Hsu, Steven M. Holland   +14 more
doaj   +6 more sources

ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination [PDF]

BMC Cancer, 2018
Background We recently reported that STAT1 plays a tumor suppressor role, and ERK was inversely correlation with STAT1 expression in esophageal squamous cell carcinoma (ESCC).
Ying Zhang, Yelong Chen, Zhaoyong Liu, Raymond Lai   +3 more
doaj   +4 more sources

STAT1/MUC4 activation promotes antimicrobial peptide production to reduce intestinal epithelium barrier injury caused by enteropathogenic Escherichia coli infection

Archives of Medical Science, 2023
Introduction Antimicrobial peptides (AMPs) are endogenous peptides that have been identified to alleviate intestinal epithelial barrier inflammation and dysfunction caused by enteropathogenic Escherichia coli (EPEC) infection; nonetheless, the upstream ...
Liu Pei, Zhigang Zuo, Meixiang Zhang, Likun Zhao, Kaishuang Li   +4 more
doaj   +2 more sources

STAT1 deficiency predisposes to spontaneous otitis media. [PDF]

PLoS ONE, 2020
Signal transducer and activator of transcription 1 (STAT1) is known to be an important player in inflammatory responses. STAT1 as a transcription factor regulates the expression of multiple proinflammatory genes.
Daniel Bodmer, Peter Kern, David Bächinger, Arianne Monge Naldi, Soledad Levano Huaman   +4 more
doaj   +4 more sources

STAT1 and STAT3 in tumorigenesis [PDF]

JAK-STAT, 2012
The transcription factors STAT1 and STAT3 appear to play opposite role in tumorigenesis. While STAT3 propmotes survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers antiproliferative and pro ...
Francesco Novelli, Valeria Poli, Regis, Gabriella, Sara Pensa, Lidia Avalle, Poli, Valeria, Pensa S., Gabriella Regis, Novelli, Francesco, Avalle, Lidia   +9 more
core   +7 more sources

Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain [PDF]

Proceedings of the National Academy of Sciences, 2008
The transcription factor Stat1 plays an essential role in responses to interferons (IFNs). Activation of Stat1 is achieved by phosphorylation on Y701 that is followed by nuclear accumulation.
Kovarik, Pavel (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Schiff, Melanie (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Schaljo-Kapp, Barbara (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Yang, Edward (The Rockefeller University), Gattermeier, Irene (Max F. Perutz Laboratories), Saalmüller, Armin (Veterinärmedizinische Universität Wien), Glinitzer, Reingard (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Sadzak, Iwona (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna), Sauer, Leonore-Ines (Department of Microbiology, Immunobiology and Genetics, Centre for Molecular Biology, University of Vienna)   +8 more
core   +3 more sources

Activation of the STAT1 pathway in rheumatoid arthritis. [PDF]

Annals of the Rheumatic Diseases, 2004
BACKGROUND: Expression of signal transducer and activator of transcription 1 (STAT1), the mediator of interferon (IFN) signalling, is raised in synovial tissue (ST) from patients with rheumatoid arthritis (RA).
van Rietschoten, J.G.I., Tak, P. P., van der Pouw Kraan, TC, Smeets, T. J., Kraan, MC, Smeets, T.J.M., Verweij, C. L., Kraan, M. C., Kasperkovitz, P.V., Verweij, C.L., Tak, P.P., van de Pouw-Kraan, T., Verbeet, N. L., Kraan, TC van der Pouw, van Rietschoten, J. G. I., Smeets, TJ, Kraan, M.C., Tak, PP, Rietschoten, J.G.I. van, Kasperkovitz, P. V., Verbeet, N.L., van der Pouw Kraan, T. C. T. M.   +21 more
core   +7 more sources

STAT1 [PDF]

Cancer Research, 2004
Abstract The anthracyclines, such as doxorubicin, are widely used in the treatment of breast cancer. Previously, we showed that these drugs could activate the transcription factor, nuclear factor κB, in a DNA damage-dependent manner.
Michelle Thomas, Clodagh E. Finnegan, Katherine M.-A. Rogers, James W. Purcell, Anne Trimble, Patrick G. Johnston, Marion P. Boland   +6 more
openaire   +1 more source

STAT1 Is Inactivated by a Caspase [PDF]

Journal of Biological Chemistry, 1998
Apoptosis involves the activation of a cascade of interleukin-1beta converting enzyme-like proteases (caspases), a group of cysteine proteases related to the prototype interleukin-1beta-converting enzyme (caspase-1). These proteases cleave specific intracellular targets such as poly(ADP-ribose) polymerase, DNA-dependent protein kinase, and nuclear ...
P, King, S, Goodbourn
openaire   +2 more sources

Redox Regulation of STAT1 and STAT3 Signaling [PDF]

International Journal of Molecular Sciences, 2020
STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes.
Butturini, Elena, Carcereri de Prati, Alessandra, Mariotto, Sofia   +2 more
openaire   +2 more sources