Results 11 to 20 of about 112,289 (303)

Quantitative specificity of STAT1 and several variants [PDF]

Nucleic Acids Research, 2017
The quantitative specificity of the STAT1 transcription factor was determined by measuring the relative affinity to hundreds of variants of the consensus binding site including variations in the length of the site. The known consensus sequence is observed to have the highest affinity, with all variants decreasing binding affinity considerably. There is
Basab Roy, Zheng Zuo, Gary D. Stormo
openaire   +6 more sources

Genetic polymorphism of stat1 and stat5a genes in holstein, jersey, and indigenous cattle breeds in turkey [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
This study aimed to determine genetic polymorphism in STAT1 and STAT5A genes for dairy cattle and some native cattle breeds in Turkey. 283 Jersey and a total of 472 Holstein cows from two different herds and 93 Grey Steppe, 85 Anatolian Black Cattle, and
Ozden COBANOGLU, Ertugrul KUL, Samet Hasan ABACI, Eser Kemal GURCAN, Soner CANKAYA   +4 more
doaj   +1 more source

BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin

Cell Adhesion & Migration, 2020
The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2.
Sonam Verma, Amandeep Kaur Kang, Rahul Pal, Satish Kumar Gupta   +3 more
doaj   +1 more source

Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment [PDF]

Open Biology, 2016
Adipose tissue is a key determinant of whole-body metabolism and energy homeostasis. Unravelling the transcriptional regulatory process during adipogenesis is therefore highly relevant from a biomedical perspective.
Xiaoming Hu, Yuanfei Zhou, Yang Yang, Jie Peng, Tongxing Song, Tao Xu, Hongkui Wei, Siwen Jiang, Jian Peng   +8 more
doaj   +1 more source

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]

, 2015
STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne, Hatziieremia, Sophia, McCall, Pamela, Mohammed, Zahra, Roseweir, Antonia K., Underwood, Mark A., Willder, Jennifer M.   +6 more
core   +1 more source

Immunomodulatory Effects of Ferula assa-foetida Extract on NF-κB and STAT1 Signaling Pathways in GM-CSF-Differentiated Human Macrophages [PDF]

Journal of Epigenetics
The immunomodulatory properties of Ferula assa-foetida, a perennial herb traditionally used for its anti-inflammatory effects, were investigated in this study, focusing on its influence on NF-κB and STAT1 signaling pathways in GM-CSF-differentiated human
Ali Abolhasanzadeh Parizi, Milad Lagzian
doaj   +1 more source

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Ambrosio G, Coffer P, Decker RS, Decker RS, Harrison DA, Luo H, Menegazzi M, Sybers HD, Townsend PA, Turkson J   +9 more
core   +1 more source

An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form

Cell Communication and Signaling, 2022
Background Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers.
Priyanka Rajeev Menon, Julia Staab, Anke Gregus, Oliver Wirths, Thomas Meyer   +4 more
doaj   +1 more source

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation

Frontiers in Cellular Neuroscience, 2023
A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and disease.
Jaime Imitola, Jaime Imitola, Ethan W. Hollingsworth, Fumihiro Watanabe, Marta Olah, Marta Olah, Wassim Elyaman, Wassim Elyaman, Sarah Starossom, Sarah Starossom, Pia Kivisäkk, Pia Kivisäkk, Samia J. Khoury, Samia J. Khoury   +13 more
doaj   +1 more source

E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity [PDF]

Cellular Signalling, 2016
Signal transducer and activator of transcription 1 (STAT1) is critically important for the transcription of a large number of immunologically relevant genes. In macrophages, interferon gamma (IFNγ) signal transduction occurs via the JAK/STAT pathway and ends with the transcription of a number of genes necessary for a successful host immune response ...
Donald W, Lawrence, Jacki, Kornbluth
openaire   +2 more sources