Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity [PDF]
, 2017 Cisplatin-induced ototoxicity is one of the major factors limiting cisplatin chemotherapy. Ototoxicity results from damage to outer hair cells (OHCs) and other regions of the cochlea.
Bhatta, Puspanjali +12 more
core +2 more sources
Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. [PDF]
PLoS Pathogens, 2012 Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interferons (IFN). Mutations of Stat1 cause severe immune deficiencies in humans and mice. Here we investigate the importance of Stat1 signaling for the innate and
Elisabeth Kernbauer +11 more
doaj +1 more source
Redox Regulation of STAT1 and STAT3 Signaling [PDF]
International Journal of Molecular Sciences, 2020 STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes.
Butturini, Elena +2 more
openaire +2 more sources
Proteomic profile of KSR1-regulated signalling in response to genotoxic agents in breast cancer [PDF]
, 2015 Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which
A Franceschini +48 more
core +3 more sources
Effect of STAT1 on Cell Cycle of Human Glioma U251 Cells and Related Mechanism
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the effect of signal transducer and activator of transcription 1 (STAT1) on cell cycle of glioma U251 cells and related mechanism.
HUANG Ping +5 more
doaj +1 more source
The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis [PDF]
, 2016 Although necrosis and necroinflammation are central features of many liver diseases, the role of programmed necrosis in the context of inflammation-dependent hepatocellular death remains to be fully determined.
Andreas E. Kremer +24 more
core +1 more source
Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo. [PDF]
PLoS ONE, 2014 Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signaling, essential in mediating host defense against viruses and other pathogens.
Nicole R Leitner +11 more
doaj +1 more source
STAT1-S727 - the license to kill [PDF]
OncoImmunology, 2014 Serine phosphorylation has generally been considered indispensable for full transcriptional activity of STAT proteins. Recent data indicate that CDK8-mediated phosphorylation of signal transducer and activator of transcription 1 (STAT1) on S727 inhibits natural killer (NK) cell cytotoxicity and restrains tumor surveillance.
Eva M, Putz +2 more
openaire +2 more sources
Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]
, 2008 Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Bachmann, Malte +3 more
core +1 more source
JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]
, 2016 The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana +5 more
core +6 more sources