Results 21 to 30 of about 82,953 (296)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1-CH25H Axis. [PDF]

Adv Sci (Weinh)
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Wu Z, Qian Y, Xu W, Liao F, Liu X, Kuang X, Luo G, He X, Jiang L, Ding S.   +9 more
europepmc   +2 more sources

Role of the STAT1-SH2 Domain and STAT2 in the Activation and Nuclear Translocation of STAT1 [PDF]

Journal of Biological Chemistry, 1998
Interferon (IFN) induction of immediate-early response genes is mediated through the signal transducers and activators of transcription (STATs). Activation of STAT1 by IFNalpha or IFNgamma through its tyrosine phosphorylation involves members of the Jak tyrosine kinases.
K, Mowen, M, David
openaire   +2 more sources

Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
core   +2 more sources

STAT1-S727 - the license to kill [PDF]

OncoImmunology, 2014
Serine phosphorylation has generally been considered indispensable for full transcriptional activity of STAT proteins. Recent data indicate that CDK8-mediated phosphorylation of signal transducer and activator of transcription 1 (STAT1) on S727 inhibits natural killer (NK) cell cytotoxicity and restrains tumor surveillance.
Eva M, Putz, Dagmar, Gotthardt, Veronika, Sexl   +2 more
openaire   +2 more sources

The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer [PDF]

, 2016
The aim of the present study was to examine the relationship between tumour cell expression of total and phosphorylated STAT1 (ph-STAT1) and STAT3 (ph-STAT-3), components of tumour microenvironment and survival in patients with invasive ductal breast ...
McMillan, Donald C., Gujam, Fadia J.A., Edwards, Joanne   +2 more
core   +1 more source

Additional file 2 of IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

, 2023
Additional file 2: Supplementary Figure 1. Infiltration of increasing activated CD8+ T cells after SCI. Supplementary Figure 2. Flow cytometry analysis showed the efficiency of transplantation or depletion (B) of CD8+ T cells in spinal cord of SCI mice ...
Ying Yao (241857), Chun-yan Fu (15236756), Jue Hu (503507), Xi Cao (316261), Deqing Peng (10171045), Ying-ying Chen (15236762), Heyangzi Li (15236753), Zhaowen Gu (15236750), Mingzhi Zheng (9471737), Jingyu Wang (292122), Xinghui Song (10522387), Lintao Xu (5772932), Lin-lin Wang (1349097), Jinjie Zhong (14369499), Yueming Ding (5947280), Yongjian Zhu (6562817), Yueliang Shen (15236759)   +16 more
core   +1 more source

Effect of STAT1 on Cell Cycle of Human Glioma U251 Cells and Related Mechanism

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the effect of signal transducer and activator of transcription 1 (STAT1) on cell cycle of glioma U251 cells and related mechanism.
HUANG Ping, DOU Changwu, JU Haitao, WANG Hongwei, XIAO Rui, NIU Lili   +5 more
doaj   +1 more source

Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. [PDF]

PLoS Pathogens, 2012
Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interferons (IFN). Mutations of Stat1 cause severe immune deficiencies in humans and mice. Here we investigate the importance of Stat1 signaling for the innate and
Elisabeth Kernbauer, Verena Maier, Dagmar Stoiber, Birgit Strobl, Christine Schneckenleithner, Veronika Sexl, Ursula Reichart, Boris Reizis, Ulrich Kalinke, Amanda Jamieson, Mathias Müller, Thomas Decker   +11 more
doaj   +1 more source

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation

Frontiers in Cellular Neuroscience, 2023
A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and disease.
Jaime Imitola, Jaime Imitola, Ethan W. Hollingsworth, Fumihiro Watanabe, Marta Olah, Marta Olah, Wassim Elyaman, Wassim Elyaman, Sarah Starossom, Sarah Starossom, Pia Kivisäkk, Pia Kivisäkk, Samia J. Khoury, Samia J. Khoury   +13 more
doaj   +1 more source

A single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species [PDF]

, 2006
The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2.
Goodbourn, S, Steve Goodbourn, Stock, N, Wang, LF, Richard Randall, Kathrin Hagmaier, Hagmaier, K, Lin-Fa Wang, Randall, R, Randall, Richard Edward, Nicola Stock, Wang, L-F   +11 more
core   +1 more source