Results 41 to 50 of about 79,832 (300)
Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]
, 2019 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R +3 more
core +2 more sources
Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]
, 2017 The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J. +3 more
core +1 more source
Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-induciblegbp2gene [PDF]
Proceedings of the National Academy of Sciences, 2007 A subgroup of genes induced by IFN-γ requires both STAT1 and IRF1 for transcriptional activation. Using WT,stat1−/−, orirf1−/−cells, we analyzed the changes induced by IFN-γ ingbp2promoter chromatin. STAT1 associated with the promoter independently of IRF1 and played an essential role in the ordered recruitment of the coactivator/histone acetyl ...
Ramsauer, Katrin +6 more
openaire +4 more sources
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]
, 2017 STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien +7 more
core +3 more sources
PLoS ONE, 2013 A transition from a parallel to an antiparallel dimer configuration of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for interferon (IFN)-mediated signal transduction. However, the precise molecular mechanisms linking conformational changes to target gene activation by STAT1 are still largely unknown ...
Staab, Julia +2 more
openaire +5 more sources
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance
Cell Reports, 2013 The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against
Eva Maria Putz +14 more
doaj +1 more source
Cell Reports, 2022 Summary: It is well known that interferon (IFN)-α/-β activates the JAK/STAT signaling pathway and suppresses viral replication through the induction of IFN stimulated genes (ISGs).
Liping Yang +11 more
doaj +1 more source
Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations
罕见病研究Signal transduction and activator of transcription factor 1(STAT1), one of the important members of the STAT family, is a key cytoplasmic transcription factor and an important component of the JAK-STAT signaling pathway.
LI Linpeng +4 more
doaj +1 more source
STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer
Molecular Oncology, 2018 The interferon‐inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex‐specific STAT1 functions in colitis and colitis‐associated colorectal cancer (CRC) using mice with specific STAT1 deletion in ...
Ilija Crnčec +17 more
doaj +1 more source
Aspergillus fumigatus preexposure worsens pathology and improves control of Mycobacterium abscessus pulmonary infection in mice [PDF]
, 2018 Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and ...
Elsegeiny, Waleed +7 more
core +2 more sources