Results 61 to 70 of about 79,832 (300)

Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - Redundancy or specificity of neuroimmunoendocrine modulators? [PDF]

, 2004
Objective: This comparative in vitro study examined the effects of all known gp130 cytokines on murine corticotroph AtT-20 cell function. Methods: Cytokines were tested at equimolar concentrations from 0.078 to 10 nM.
Auernhammer, Christoph J., Cengic, N., Dorn, F., Engelhardt, D., Isele, N. B., Kopp, F. B., Senaldi, G., Spottl, G., Vlotides, G., Weber, M. M.   +9 more
core   +1 more source

Protein Inhibitor of Activated STAT1 Interacts with and Up-regulates Activities of the Pro-proliferative Transcription Factor Krüppel-like Factor 5 [PDF]

Journal of Biological Chemistry, 2007
Krüppel-like factor 5 (KLF5) is a zinc finger-containing transcription factor that regulates proliferation of various cell types, including fibroblasts, smooth muscle cells, and intestinal epithelial cells. To identify proteins that interact with KLF5, we performed a yeast two-hybrid screen of a 17-day mouse embryo cDNA library with KLF5 as bait.
James X, Du, C Chris, Yun, Agnieszka, Bialkowska, Vincent W, Yang   +3 more
openaire   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

STAT1-Dependent Recruitment of Ly6C^hiCCR2⁺ Inflammatory Monocytes and M2 Macrophages in a Helminth Infection

Pathogens, 2021
Signal Transducer and Activator of Transcription (STAT) 1 signaling is critical for IFN-γ-mediated immune responses and resistance to protozoan and viral infections.
Mireya Becerra-Díaz, Yadira Ledesma-Soto, Jonadab E. Olguín, Angel Sánchez-Barrera, Mónica G. Mendoza-Rodríguez, Sandy Reyes, Abhay R. Satoskar, Luis I. Terrazas   +7 more
doaj   +1 more source

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]

, 2008
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Brune, Verena, Bräuninger, Andreas, Döring, Claudia, Eckerle, Susan, Falini, Brunangelo, Hansmann, Martin-Leo, Heydebreck, Anja von, Klapper, Wolfram, Küppers, Ralf, Metzler, Dirk, Pfeil, Ines, Tiacci, Enrico, van Noesel, Carel J. M.   +12 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

STAT1 as a potential prognosis marker for poor outcomes of early stage colorectal cancer with microsatellite instability.

PLoS ONE, 2020
Proteomic analyses indicate that STAT1 protein (signal transducer and activator of transcription 1 or transcription factor ISGF-3 components p91/p84) is upregulated in some colorectal cancers.
Atsushi Tanaka, Yihua Zhou, Makiko Ogawa, Jinru Shia, David S Klimstra, Julia Y Wang, Michael H Roehrl   +6 more
doaj   +1 more source

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [PDF]

, 2019
BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms
Aran, Dvir, Butte, Atul J, Greene, Warner C, Hsieh, Christine, Joshi, Sunil, Kim, Peggy, Montano, Mauricio, Morón-López, Sara, Telwatte, Sushama, Wong, Joseph K, Yukl, Steven A   +10 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Transcription factor networks involved in cell death in the dorsal root ganglia following peripheral nerve injury

Neural Regeneration Research, 2018
The peripheral nervous system has the potential to regenerate after nerve injury owing to the intrinsic regrowth ability of neurons and the permissive microenvironment.
Jing Qin, Jian-Cheng Wu, Qi-Hui Wang, Song-Lin Zhou, Su-Su Mao, Chun Yao   +5 more
doaj   +1 more source