Results 51 to 60 of about 79,832 (300)

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.

PLoS Pathogens, 2016
STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1).
Ying Ren, Peng Zhao, Jin Liu, Yukang Yuan, Qiao Cheng, Yibo Zuo, Liping Qian, Chang Liu, Tingting Guo, Liting Zhang, Xiaofang Wang, Guanghui Qian, Lemin Li, Jun Ge, Jianfeng Dai, Sidong Xiong, Hui Zheng   +16 more
doaj   +1 more source

Gene Activation by the Cytokine-Driven Transcription Factor STAT1

, 2019
Signal transducers and activators of transcription (STATs) are a family of cytokine-regulated transcription factors, which serve the dual role of external signal transduction and transcriptional activation. The founding member of this family, STAT1, is involved in a plethora of cellular processes, including interferon-dependent upregulation of various ...
Nast, Roswitha, Staab, Julia, Meyer, Thomas, Behzadi, Payam   +3 more
openaire   +4 more sources

Activation of Raf-1 by Interferon γ and Oncostatin M Requires Expression of the Stat1 Transcription Factor [PDF]

Journal of Biological Chemistry, 1998
A primary signaling cascade responsible for the expression of cytokine-stimulated immediate early genes involves the activation of the Jak/Stat pathway. In addition to being tyrosine-phosphorylated, several signal transducers and activators of transcription (Stats), including Stat1alpha, Stat3, and Stat4, are phosphorylated on a conserved serine ...
L F, Stancato, C R, Yu, E F, Petricoin, A C, Larner   +3 more
openaire   +2 more sources

STAT1 signaling protects self-reactive T cells from control by innate cells during neuroinflammation

JCI Insight, 2022
The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4+ T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS)
Carlos A. Arbelaez, Pushpalatha Palle, Jonathan Charaix, Estelle Bettelli   +3 more
doaj   +1 more source

A flexible integrative approach based on random forest improves prediction of transcription factor binding sites [PDF]

, 2012
Transcription factor binding sites (TFBSs) are DNA sequences of 6-15 base pairs. Interaction of these TFBSs with transcription factors (TFs) is largely responsible for most spatiotemporal gene expression patterns.
Abeel, Afflerbach, Angarica, Bailey, Bart Hooghe, Bauer, Benos, Breiman, Bulyk, Burden, Calladine, Camenisch, Chen, Cho, Cordell, Davis, Dickerson, Ehret, Ernst, Frans van Roy, Friedel, Fujii, Fulton, Gama-Castro, Gardiner, Gartenberg, Gershenzon, Goodsell, Gorin, Gowrisankar, Greenbaum, Gunewardena, Hall, Hendrickson, Hu, Juo, Kajimura, Kaplan, Karas, Kel, Kim, Lavery, Lewis, Liu, Liu, Liu, Long, Lu, Lu, Lu, Lunetta, Man, Marco, Marinescu, Martinez-Hackert, Matys, Medina-Rivera, Meysman, Michel, Mokry, Morozov, Narang, Naughton, O'Flanagan, Olson, Paillard, Pan, Parker, Parvin, Pieter De Bleser, Ponomarenko, Portales-Casamar, Powell, Pudimat, Ramsey, Rohs, Rohs, Rohs, Ruiz, Satchwell, Schneider, Shakked, Sharon, Shi, Spolar, Stefan Broos, Stormo, Svozil, Thayer, Tomovic, Toro-Roman, Travers, Tullius, Wunderlich, Zhang, Zhang, Zhu   +96 more
core   +2 more sources

Oxidized LDL activates STAT1 and STAT3 transcription factors: possible involvement of reactive oxygen species

FEBS Letters, 1999
The effect of cupric ion‐oxidized low density lipoprotein (Cu‐LDL) or endothelial cell‐oxidized LDL (E‐LDL) on STAT1 and STAT3 (signal transducers and activators of transcription) DNA binding activity was investigated by electrophoretic mobility shift assay in human endothelial cells.
Mazière, Cécile, Alimardani, Gulie, Dantin, Françoise, Dubois, Françoise, Conte, Marie-Alix, Mazière, Jean-Claude   +5 more
openaire   +2 more sources

STAT1 and Nmi are downstream targets of Ets‐1 transcription factor in MCF‐7 human breast cancer cell [PDF]

FEBS Letters, 2005
Ets‐1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue‐specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis.
Jung, Hae Hyun, Lee, Jeeyun, Kim, Joo Hyun, Ryu, Kyoung-Ju, Kang, Sun-A, Park, Chaehwa, Sung, Kiwoong, Nam, Do-Hyun, Kang, Won Ki, Park, Keunchil, Im, Young-Hyuck   +10 more
openaire   +2 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription

Frontiers in Immunology, 2019
Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by atherosclerotic lesion formation. Vascular Smooth Muscle Cells (VSMC), macrophages (MΦ), and dendritic cells (DC) play a crucial role in vascular inflammation and ...
Anna Piaszyk-Borychowska, Lajos Széles, Attila Csermely, Hsin-Chien Chiang, Joanna Wesoły, Chien-Kuo Lee, Laszlo Nagy, Laszlo Nagy, Hans A. R. Bluyssen   +8 more
doaj   +1 more source

Viral modulation of interferon (IFN) responses to african swine fever virus (ASFV) [PDF]

, 2011
Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011A imunidade inata constitui a primeira resposta dada por um hospedeiro quando atacado por agentes patogénicos. A resposta imune baseia-se em genes
Costa, Emanuel Nery de Oliveira Quartin, 1986-
core