Results 81 to 90 of about 4,584,115 (291)

Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon [PDF]

, 2002
Production of alpha/beta interferons (IFN-α/β) in response to viral infection is one of the main defense mechanisms of the innate immune system. Many viruses therefore encode factors that subvert the IFN system to enhance their virulence.
Richard E. Randall, Randall, Richard E, Friedemann Weber, Fazakerley, John K., Nina Kessler, Weber, F, Elliott, Richard M., Fazakerley, John K, Weber, Friedemann, Weber, F., Streitenfeld, Hein, Elliott, Richard M, Randall, R.E., Kessler, N, Elliott, R.M., Streitenfeld, H., Richard M. Elliott, Kessler, N., Anne Bridgen, Bridgen, A., Streitenfeld, H, Fazakerley, J.K., Kessler, Nina, Hein Streitenfeld, Bridgen, A, Elliott, Richard Michael, Fazakerley, JK, John K. Fazakerley, Bridgen, Anne, Randall, Richard Edward   +29 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

STAT1 and Nmi are downstream targets of Ets‐1 transcription factor in MCF‐7 human breast cancer cell [PDF]

FEBS Letters, 2005
Ets‐1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue‐specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis.
Jung, Hae Hyun, Lee, Jeeyun, Kim, Joo Hyun, Ryu, Kyoung-Ju, Kang, Sun-A, Park, Chaehwa, Sung, Kiwoong, Nam, Do-Hyun, Kang, Won Ki, Park, Keunchil, Im, Young-Hyuck   +10 more
openaire   +2 more sources

Functional analysis of the competence transcription factor ComK of Bacillus subtilis by characterization of truncation variants [PDF]

, 2005
The competence transcription factor ComK is the master regulator of competence development in Bacillus subtilis. In the regulatory pathway, ComK is involved in different interactions: (i) protein–DNA interactions to stimulate transcription of ComK ...
Andy-Mark W. H. Thunnissen, Thunnissen, Andy-Mark W.H.,, Thunnissen, A.M.W.H.; id_orcid, Oscar P. Kuipers, Fusetti, F., Fabrizia Fusetti, Hamoen, L.W, Susanna, Kim, Kim A. Susanna, Susanna, Kim Amé,, Kuipers, Oscar P.,, Susanna, Kim A.,, Fusetti, Fabrizia,, Kuipers, O.P., Hamoen, Leendert W.,, Susanna, Kim Amé, Kuipers, O.P.; id_orcid, Thunnissen, A.M.W.H., Leendert W. Hamoen   +18 more
core   +2 more sources

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Clinically Relevant Dimer Interface Mutants of STAT1 Transcription Factor Exhibit Differential Gene Expression

PLoS ONE, 2013
A transition from a parallel to an antiparallel dimer configuration of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for interferon (IFN)-mediated signal transduction. However, the precise molecular mechanisms linking conformational changes to target gene activation by STAT1 are still largely unknown ...
Staab, Julia, Herrmann-Lingen, Christoph, Meyer, Thomas   +2 more
openaire   +5 more sources

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis

Molecular Medicine, 2023
Background Osteoarthritis (OA) is a degenerative joint disease with lacking effective prevention targets. A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12) is a member of the ADAMTS family and is upregulated in OA pathologic ...
Shu Yang, Xuanping Zhou, Zhen Jia, Mali Zhang, Minghao Yuan, Yizhao Zhou, Jing Wang, Duo Xia   +7 more
doaj   +1 more source

Oxidized LDL activates STAT1 and STAT3 transcription factors: possible involvement of reactive oxygen species

FEBS Letters, 1999
The effect of cupric ion‐oxidized low density lipoprotein (Cu‐LDL) or endothelial cell‐oxidized LDL (E‐LDL) on STAT1 and STAT3 (signal transducers and activators of transcription) DNA binding activity was investigated by electrophoretic mobility shift assay in human endothelial cells.
Mazière, Cécile, Alimardani, Gulie, Dantin, Françoise, Dubois, Françoise, Conte, Marie-Alix, Mazière, Jean-Claude   +5 more
openaire   +2 more sources