Results 51 to 60 of about 1,741,412 (341)
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Soma-Axon Coupling Configurations That Enhance Neuronal Coincidence Detection [PDF]
, 2019 Coincidence detector neurons transmit timing information by responding preferentially to concurrent synaptic inputs. Principal cells of the medial superior olive (MSO) in the mammalian auditory brainstem are superb coincidence detectors.
Goldwyn, Joshua H. +2 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Journal of Family Medicine and Primary CareBackground: Brucellosis is a re-emerging zoonosis with global distribution. In India, it remains common but often neglected. In Rajasthan, where agriculture is prevalent, frequent contact with infected animals such as goats, sheep, and cattle leads to ...
Usha Verma, Prabhu Prakash
doaj +1 more source
Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway
Frontiers in Pharmacology, 2021 The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response.
Qianqian Yin +5 more
semanticscholar +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Recovering Individual Data In The Presence Of Group And Individual Effects [PDF]
, 1973 The ecological fallacy of relating variables on the group level, when the individual-level relationship is desired, can only be avoided by using individual-level data.
Iversen, Gudmund R.
core +3 more sources
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
Cell Communication and Signaling, 2017 The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells.
F. Seif +5 more
semanticscholar +1 more source
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy
Cells, 2020 Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis.
S. Bose +6 more
semanticscholar +1 more source