Results 141 to 150 of about 273,588 (361)
Highlighted STAT3 as a potential drug target for cancer therapy
BMB Reports, 2019 Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation and immune responses.
Haeri Lee, A. Jeong, S. Ye
semanticscholar +1 more source
Signal transducer and activator of transcription 3 (Stat3) phosphorylation in primary breast cancer
, 2011 Copyright information:Taken from "Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer"http://breast-cancer-research.com/content/9/3/R32Breast Cancer Research 2007;9(3):R32-R32.Published online
Hikmat Al-Ahmadie (77202) +7 more
core +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Journal of Inflammation ResearchTao Yang,1,2,* Pengcui Wu,2,* Luping Jiang,2 Ran Chen,2 Qiao Jin,2 Guohong Ye2 1Department of Cardiovascular Medicine, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s ...
Yang T +5 more
doaj
Detection of Leptin Activity in Living Cells Expressing Chicken Leptin Receptor and STAT3
The Journal of Poultry Science, 2012 The chicken leptin receptor (chLEPR) activates Janus kinase (JAK) - signal transducers and activator of transcription (STAT) signaling pathway after leptin stimulation.
Hiromi Adachi +3 more
doaj +1 more source
The Role of STAT3 in acute inflammatory hepatitis
, 2010 利用在小鼠體內注射入Concanavalin A (Con A)所引起之嚴重肝臟病變是一個用來研究人類猛暴性肝炎或自體免疫引起之肝炎的很好的動物模式，但其致病機轉至今仍尚未完全明朗。為了釐清在Con A 引起之肝炎中STAT3 在肝細胞內扮演的角色，我們使用只在肝細胞中剔除STAT3基因(STAT3KO)的小鼠作為通篇研究的實驗材料。根據先前的研究，我們發現在Con A刺激下STAT3KO小鼠血清中的ALT/AST數值以及肝臟受損程度相較於正常小鼠都是較低的。利用體外培養的系統 ...
Lee, Priscilla, 李靜蓉
core
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling
Frontiers in ImmunologyLiver macrophages play a role in the development of liver fibrosis progression via the regulation of inflammatory signaling. However, the precise mechanisms of macrophages contributing to liver fibrosis progression remain unclear.
Soo-Jeung Park +5 more
doaj +1 more source
Cancer Management and Research, 2021 Jing-Min Zheng,1,* Han-Xi Zhou,1,* Hong-Yuan Yu,1,* Yu-Hui Xia,2 Qing-Xin Yu,2 Hang-Shuai Qu,1 Jia-Qian Bao1 1Department of Urology, Taizhou Hospital, Wenzhou Medical University, Linhai, Zhejiang, People’s Republic of China; 2Department of ...
Zheng JM +6 more
doaj
A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction
Aging, 2010 The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view of a core function determining this widespread STAT3-dependence has yet emerged. We show here that constitutively active STAT3 acts as a master regulator of cell metabolism, inducing ...
Demaria M +13 more
openaire +3 more sources