Results 151 to 160 of about 273,588 (361)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Editorial: Chemokine receptors and signaling in wound healing

Frontiers in Pharmacology, 2023
Zhenlong Chen, Richard D. Minshall
doaj   +1 more source

Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy

International Journal of Nanomedicine, 2022
Tingting Chen,1,2,* Bingxiang Ma,1,2,* Shi Lu,1,2 Lupeng Zeng,1,2 Huaying Wang,1,2 Wanhua Shi,1,2 Linying Zhou,3 Yaokun Xia,4 Xi Zhang,1 Jing Zhang,5 Jinghua Chen1 1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, 350108 ...
Chen T, Ma B, Lu S, Zeng L, Wang H, Shi W, Zhou L, Xia Y, Zhang X, Zhang J, Chen J   +10 more
doaj  

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.

Genes & Development, 1998
The propagation of embryonic stem (ES) cells in an undifferentiated pluripotent state is dependent on leukemia inhibitory factor (LIF) or related cytokines. These factors act through receptor complexes containing the signal transducer gp130.
H. Niwa, T. Burdon, I. Chambers, Austin G Smith   +3 more
semanticscholar   +1 more source

Kelidonin hatása a STAT3 szerin foszforilációjára és intracelluláris lokalizációjára humán uveális melanóma sejtvonalakon

, 2015
Itt bemutatott kísérleteinkben a benzofenantridinvázas alkaloidok családjába tartozó kelidonin hatását vizsgáltuk a STAT3 transzkripciós faktor foszforilációjára uveális melanóma sejteken.
Nádasi, Márton
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

ARHI (DIRAS 3), an Imprinted Tumor Suppressor Gene, Binds to Importins, and Blocks Nuclear Translocation of Stat3

, 2008
ARHI (DIRAS3) is an imprinted tumor suppressor gene whose expression is lost in the majority of breast and ovarian cancers. Unlike its homologs Ras and Rap, ARHI functions as a tumor suppressor.
Wenbo Lin, Yiling Lu, In Soon Chang, Robert Bast, Jr., Warren Liao, Shaoyi Huang, Zhen Lu, Tao Tao, Ke Zhang, Robert Luo, Yinhua Yu, Xiaomin Chen   +11 more
core  

The Tim-3-Fyn-STAT3-C/EBPβ pathway mediates Arg-1 and IL-10 expression in MDSCs following T. gondii infection.

, 2023
(A) Western blot analysis and statistical analysis of the expression of STAT3, phosphorylated (p)-STAT3, C/EBPβ, Arg-1, and IL-10 in MDSCs treated with αTim-3 or artificial recombinant galectin-9 (rGal-9) during T. gondii infection.
Xuemei Hu (283962), Yuantao Li (1901074), Xianbing Liu (285135), Yuzhu Jiang (285136), Xiaoyan Xu (283959), Haixia Zhang (283960), Zhidan Li (10938945), Houbao Qi (11996039)   +7 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source