Results 191 to 200 of about 273,588 (361)

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Characterization of a gp130 Signaling Receptor Polymorphism [PDF]

, 2013
We previously reported an association between human herpesvirus 8 (HHV-8) seroprevalence and increased prostate cancer risk among men on the Caribbean island of Tobago.
Kercher, Katherine
core  

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Very-early-onset autoimmune hypothyroidism: a report of two cases with STAT3 gain-of-function variant

European Thyroid Journal
Autoimmune hypothyroidism occurs rarely before 3 years of age. Two siblings were diagnosed with autoimmune hypothyroidism at age 5 and 16 months, presenting with classic symptoms of hypothyroidism, abnormal thyroid function tests (TSH: 200 and 660 mU/L ...
Rowmika Ravi, Anita Niskanen, Mary Pat Reeve, Kristiina Makkonen, Harri Niinikoski, Jorma Toppari, Jukka Kero   +6 more
doaj   +1 more source

Role of Stat3 in Fyn kinase-mediated dopaminergic neurodegeneration and microglia activation

openLa chinasi Fyn, identificata come locus di rischio per le malattie di Alzheimer e Parkinson, svolge un ruolo chiave nei processi di neurodegenerazione e infiammazione.
DI MATOLA, UMBERTO
core  

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Negative regulators of STAT3 signaling pathway in cancers

, 2019
Moli Wu,1,2,* Danyang Song,1,* Hui Li,1 Yang Yang,1 Xiaodong Ma,1 Sa Deng,1 Changle Ren,3 Xiaohong Shu11College of Pharmacy, Dalian Medical University, Dalian 116044, People’s Republic of China; 2College of Basic Medical Sciences, Dalian Medical ...
Li H, Deng S, Wu M, Yang Y, Song D, Ma X, Shu X, Ren C   +7 more
core  

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein

, 2005
Tumors have evolved elaborate mechanisms for evading immune detection, such as production of immunoinhibitory cytokines and down-regulation of major histocompatibility complex (MHC) expression.
Hubank, M, Antigoni Papanastasiou, Nabarro, S, Sebire, N, Himoudi, N, Papanastasiou, A, Blundell, MP, Gibson, S, Gilmour, K, Anderson, J, Adrian Thrasher, Neil Sebire, John Anderson, Mike Hubank, Nourredine Himoudi, Kimberly Gilmour, Sian Gibson, Canderan, G, Stephen Nabarro, Glenda Canderan, Thrasher, A, Michael P. Blundell   +21 more
core   +1 more source

Role of STAT3 in pancreatic cancer

Exploration of Targeted Anti-tumor Therapy
Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the signal transducer and activator of transcription (STAT) family of proteins in pancreatic tumors.
Zachary Hamel, Sierra Sanchez, David Standing, Shrikant Anant   +3 more
openaire   +3 more sources

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source