Results 271 to 280 of about 273,588 (361)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

OCT4 and NANOG are involved in adrenocortical tumorigenesis. [PDF]

Arch Endocrinol Metab
Cavalcanti MM, Halah MP, Leal LF, Coeli-Lacchini FB, Scrideli CA, Molina CAF, Yunes JA, Brandalise S, Moreira AC, Ramalho F, Ramalho LN, Castro M, Antonini SR.   +12 more
europepmc   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

IL-6-driven POU2AF1 and ELL2 are key regulators of multiple myeloma-distinct transcriptional and splicing programs. [PDF]

Blood Adv
Ohguchi Y, Ajiro M, Ogiya D, Masuda T, Kawano Y, Usuki S, Koga T, Hino S, Harada T, Takahashi S, Okada S, Yasunaga JI, Sashida G, Ohtsuki S, Nakao M, Minami T, Yoshimi A, Ohguchi H.   +17 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Pharmacological inhibition of LIF signaling reverses PD-L1-mediated immune suppression in gastric cancer. [PDF]

Transl Oncol
Di Giorgio C, Marchianò S, Biagioli M, Lachi G, Massa C, Sensini B, Giannelli E, Sette MR, Urbani G, Paniconi F, Cari L, Monti MC, Sepe V, Natalizi N, Graziosi L, Distrutti E, Donini A, Zampella A, Fiorucci S.   +18 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis. [PDF]

Signal Transduct Target Ther
He CC, Lei MX, Jiang JW, Zhang T, Lai YP, Qi RQ, Gao XH.   +6 more
europepmc   +1 more source

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Cell Cycle, 2018
Xianmin Mu, W. Shi, Yue Xu, Che Xu, T. Zhao, B. Geng, Jing Yang, Jinshun Pan, S-H Hu, Chen Zhang, Juan Zhang, Chao Wang, Jiajia Shen, Y. Che, Zheng Liu, Yuanfang Lv, Hao Wen, Q. You   +17 more
semanticscholar   +1 more source