Results 91 to 100 of about 29,169,368 (250)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Optimal Control of a Flexible Spacecraft in a Proximity Operation Using State Dependent Riccati Equation Approach [PDF]
فصلنامه علوم و فناوری فضایی, 2015 This paper presents a suitable technique for nonlinear control of a flexible spacecraft in proximity operations. To do proximity operations well, the pursuer spacecraft must place itself in a pre specified location relative to target and align its ...
Mohammad Reza Mortazavi +1 more
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The administration of the Aid to Dependent Children's Law (Mothers' Pension Law) in Wisconsin.
Latest issue consulted: 1921.Description based first issue; title from title page.Mode of access: Internet.Reports submitted to the State Board of ...
Wisconsin. State Board of Control.
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Attitude Control of Spacecraft by State Dependent Riccati Equation and Power Series Expansion of Riccati Methods [PDF]
فصلنامه علوم و فناوری فضایی, 2015 Attitude control of spacecraft in order to nonlinear and high order dynamics is fundamental and challenging issue. With respect to these nonlinearities, linear control theories are not suitable choices and spacecraft may be unstable or lose performance ...
M. Navabi, M. Tavana, H.R. Mirzaei
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Dependent Care Assistance Program
Title from home page updated to 11/20/07 (viewed Dec.
State of Connecticut Dependent Care Assistance Program.
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