Results 71 to 80 of about 307,060 (286)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A transverse Hamiltonian variational technique for open quantum stochastic systems and its application to coherent quantum control

, 2015
This paper is concerned with variational methods for nonlinear open quantum systems with Markovian dynamics governed by Hudson-Parthasarathy quantum stochastic differential equations.
Vladimirov, Igor G.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

NONLINEAR DYNAMICS OF THE MAGNETIC ROTOR BEARING SYSTEM WITH RUB-IMPACT FORCE

Jixie qiangdu, 2020
In order to investigate the transient nonlinear dynamic behavior in connection to the contract between the auxiliary bearing and magnetic rotor under high-speed rotation,bifurcation diagrams,time responses,Poincaré sections and phrase diagrams are ...
XU Lu, RAO XiaoBo, CHU YanDong
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

H_221E; Switched Controller Design for a Class of Uncertain Linear Systems Using Derivative Feedback

IEEE Access
This manuscript proposes ${\mathcal {H}}_{\infty }$ switched controller designs for a class of linear systems with time-invariant uncertainties, where only the derivative of the state vector is used for feedback.
Leidy D. Wolmuth, Uiliam Nelson L. T. Alves, Andre Krindges, Rodrigo Cardim, Edvaldo Assuncao, Marcelo C. M. Teixeira   +5 more
doaj   +1 more source

Nonlinear Synergetic Governor Controllers for Steam Turbine Generators to Enhance Power System Stability

Energies, 2017
This paper proposes a decentralized nonlinear synergetic governor controller (NSGC) for turbine generators to enhance power system stability by using synergetic control theory and the feedback linearization technique.
Xingbao Ju, Ping Zhao, Haishun Sun, Wei Yao, Jinyu Wen   +4 more
doaj   +1 more source

Direct Design of Controllers Using Complementary State and State-Derivative Feedback

Journal of Control, Automation and Electrical Systems, 2019
This paper is concerned with controllers design using complementary state and state-derivative feedback, as an extension of the work presented in Rossi et al. (in: Proceedings of XXI Congresso Brasileiro de Automatica, Vitoria, Brazil, pp 828–833, 2016).
Fernanda Quelho Rossi, Roberto Kawakami Harrop Galvão, Marcelo Carvalho Minhoto Teixeira, Edvaldo Assunção   +3 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source