Results 81 to 90 of about 852,124 (258)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dynamic Linear Models for Wastewater-Based Epidemiology with Missing Values: an Application to Covid-19 Surveillance

Data Science in Science
We argue for the usage of dynamic linear models (DLMs) for pre-processing and modeling of wastewater data used for surveillance of population infectious disease levels.
Difan Ouyang, Lappui Chung, Mark Osborn, Timothy W. Schacker, Charles R. Doss   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Nonlinear Hierarchical Time Series Approach to Citywide Trend Assessment of Viruses, Hot Spot Signals, and Right-Sizing System

Data Science in Science
Wastewater surveillance has proven to be a cost-effective cornerstone in public health, offering vital insights into a spectrum of community health issues, particularly during the COVID-19 pandemic.
Katherine B. Ensor, Julia C. Schedler, Jose Palacio, Rebecca Schneider, Kaavya Domakonda, Loren Hopkins, Lauren B. Stadler   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Balancing Precision and Efficiency: Cross-View Geo-Localization with Efficient State Space Models

AI
Cross-view geo-localization tries to find the matching place in large satellite or aerial pictures from photos taken at ground level, which is useful for applications like self-driving cars, flying drones, and adding virtual objects to real city scenes ...
Haojie Tao, Shixin Wang, Futao Wang, Litao Wang, Zhenqing Wang, Zhaowei Wang, Tianhao Wang, Chengyue Xiong, Ziqi Nie   +8 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DFS-YOLO: A Dynamic Feature Collaboration and State Space Framework for UAV-Based Infrared Object Detection

Remote Sensing
UAV-based infrared target detection presents inherent challenges, including low signal-to-noise ratios, texture degradation, and severe scale variations. To address these issues, we propose DFS-YOLO, an approach based on dynamic feature collaboration and
Ziyan Wang, Wangbin Li, Kaimin Sun
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Multi-Scale Feature Fusion Dual-Branch Mamba-CNN Network for Landslide Extraction

Applied Sciences
Automatically extracting landslide regions from remote sensing images plays a vital role in the landslide inventory compilation. However, this task remains challenging due to the considerable diversity of landslides in terms of morphology, triggering ...
Zhiheng Yang, Hua Zhang, Nanshan Zheng
doaj   +1 more source