Results 51 to 60 of about 3,753,525 (298)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Report on the review of management of Scottish further education colleges [PDF]

, 2000
"In March 1999 Mrs Helen Liddell, then the Scottish Office Minister of State for Education, announced that the Scottish Further Education Funding Council (SFEFC) was being asked to undertake a major review of the management of Scotland’s further ...

core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Latvia's democratic resistance: a forgotten episode from the Second World War [PDF]

, 2009
In summer 1943 politicians representing the four main political parties of Latvia's democratic years came together to establish a movement which would both resist the German occupation and prevent the return of the Red Army. They considered the key to re-
Swain, G.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

La revisión del concordato de 1953: la reunión entre Casaroli y López Rodó (noviembre de 1973)

Hispania Sacra, 2003
El Concilio Vaticano II constituyó un impulso decisivo para la transformación de la relación Iglesia-Estado en España. El Concordato de 1953, que era el marco jurídico que regulaba la relación entre el catolicismo y el Régimen de Franco, hubo de ser ...
Pablo Martín de Santa Olalla Saludes
doaj   +1 more source

Donor Diversity through Public Matching Funds [PDF]

, 2012
New York State is considering a system of public campaign financing for state elections similar to the one New York City uses for municipal elections. In that system, the city puts up six dollars in public matching funds for each of the first $175 that a
Brendan Glavin, Elisabeth Genn, Michael J. Malbin, Sundeep Iyer   +3 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

EL ESTADO AUTONÓMICO UNITARIO Y EL INFORME DEL CONSEJO DE ESTADO SOBRE LA INSERCIÓN DEL DERECHO EUROPEO EN EL ORDENAMIENTO ESPAÑOL [PDF]

Revista d'Estudis Autonòmics i Federals, 2009
This paper analyses one section of the report by the Spanish council of stateon the implementation of European law in the Spanish legal order, specificallydiscussing the suggestions put forward to order the relationship betweenstate law and autonomous ...
Miguel Azpitarte Sánchez
doaj  

Does the Plenary Session of the Italian State Council Become a Common Law Judge?

Studia Iuridica Lublinensia, 2018
The article embraces the question of competence of the Italian Council of State (Consiglio di Stato) in the light of orders referred to in Article 99 of the Italian Administrative Procedure Code.
Giovanni Pesce
doaj   +1 more source