Results 61 to 70 of about 837,136 (306)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

KONCEPCJA USTANOWIENIA RADY STANU (W ZWIąZKU Z PROJEKTEM RZECZNIKA PRAW OBYWATELSKICH JANUSZA KOCHANOWSKIEGO)

open access: yesZeszyty Prawnicze, 2016
A PROPOSAL TO ESTABLISH A COUNCIL OF STATE IN POLAND Summary In 2006 Janusz Kochanowski, Poland’s Civil Rights Spokesman, put forward a proposal for the establishment of a council of state.
Marek Krzymkowski
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

EL ESTADO AUTONÓMICO UNITARIO Y EL INFORME DEL CONSEJO DE ESTADO SOBRE LA INSERCIÓN DEL DERECHO EUROPEO EN EL ORDENAMIENTO ESPAÑOL [PDF]

open access: yesRevista d'Estudis Autonòmics i Federals, 2009
This paper analyses one section of the report by the Spanish council of stateon the implementation of European law in the Spanish legal order, specificallydiscussing the suggestions put forward to order the relationship betweenstate law and autonomous ...
Miguel Azpitarte Sánchez
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Other title: May Council meeting, progress report [PDF]

open access: yes, 1958
"May 1958."MAY COUNCIL MEETING -- Status of Council Work -- Legislative Committee on Economy and Efficiency - Fourth Interim Report -- COUNCIL ACTION ON PROPOSALS -- Educational Survey - Pro. No. 7 -- Charges for Care in State Hospitals - Pro. No.
Kansas. Legislature. Legislative Council.
core  

La revisión del concordato de 1953: la reunión entre Casaroli y López Rodó (noviembre de 1973)

open access: yesHispania Sacra, 2003
El Concilio Vaticano II constituyó un impulso decisivo para la transformación de la relación Iglesia-Estado en España. El Concordato de 1953, que era el marco jurídico que regulaba la relación entre el catolicismo y el Régimen de Franco, hubo de ser ...
Pablo Martín de Santa Olalla Saludes
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Other title: September Council meeting : progress report [PDF]

open access: yes, 1947
"September 1947."SEPTEMBER COUNCIL MEETING -- Status of Council Work -- New Proposals Introduced -- COMMITTEE ACTIVITY AND REPORTS -- Agriculture and Livestock -- Assessment and Taxation -- Proposal 5, Tax-Exempt Government Property -- Proposal 8 ...
Kansas. Legislature. Legislative Council.
core  

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