Results 51 to 60 of about 19,255,488 (244)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

EL ESTADO AUTONÓMICO UNITARIO Y EL INFORME DEL CONSEJO DE ESTADO SOBRE LA INSERCIÓN DEL DERECHO EUROPEO EN EL ORDENAMIENTO ESPAÑOL [PDF]

open access: yesRevista d'Estudis Autonòmics i Federals, 2009
This paper analyses one section of the report by the Spanish council of stateon the implementation of European law in the Spanish legal order, specificallydiscussing the suggestions put forward to order the relationship betweenstate law and autonomous ...
Miguel Azpitarte Sánchez
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Other title: SRC annual report; Other title: State Rehabilitation Council annual report

open access: yes, 2013
Annual; Report year ends Sept. 30.; Issued by: State Rehabilitation Advisory Council, -2000/2001; by the State Rehabilitation Council, 2001 ...
Connecticut. State Rehabilitation Council.
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

La revisión del concordato de 1953: la reunión entre Casaroli y López Rodó (noviembre de 1973)

open access: yesHispania Sacra, 2003
El Concilio Vaticano II constituyó un impulso decisivo para la transformación de la relación Iglesia-Estado en España. El Concordato de 1953, que era el marco jurídico que regulaba la relación entre el catolicismo y el Régimen de Franco, hubo de ser ...
Pablo Martín de Santa Olalla Saludes
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Does the Plenary Session of the Italian State Council Become a Common Law Judge?

open access: yesStudia Iuridica Lublinensia, 2018
The article embraces the question of competence of the Italian Council of State (Consiglio di Stato) in the light of orders referred to in Article 99 of the Italian Administrative Procedure Code.
Giovanni Pesce
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

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