Results 111 to 120 of about 2,837,797 (287)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Optimizing decentralized implementation of state estimation in active distribution networks

IET Generation, Transmission & Distribution
The challenges facing active distribution networks have highlighted the position of the distribution system state estimation (DSSE) process in the distribution management systems as its most important function.
Mohammad Gholami, Aref Eskandari, Sajjad Fattaheian‐Dehkordi, Matti Lehtonen   +3 more
doaj   +1 more source

Key Technology and Development Prospect of Ontology Safety for Lithium-Ion Battery Storage Power Stations

Zhongguo dianli
The introduction of the "dual carbon" targets and the ongoing advancement of low-carbon transitions in energy and electricity have posed significant challenges to the new-type power system, which primarily relies on renewable energy sources, particularly
Xiangyang XIA, Xinxin TAN, Zhouping SHAN, Hui LI, Zhiqiang XU, Jinbo WU, Jiahui YUE, Guiquan CHEN   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Linear Matrix Inequalities in Fault Detection Filter Design for Linear Ostensible Metzler Systems

Machines
The article deals with the properties of fault detection filters when applying their structure to a class of linear, continuous-time systems, with dynamics being specified by the system matrix of the ostensible Metzler structure. The proposed solution is
Dušan Krokavec, Anna Filasová
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

State Estimation and Fault Diagnosis of Proton Exchange Membrane Fuel Cells Based on Artificial Intelligence

发电技术
ObjectivesThe proton exchange membrane fuel cell (PEMFC), as a highly promising clean energy technology, has attracted much attention in the field of energy conversion.
ZHENG Ruyi, YANG Bo, ZHOU Shuai, JIANG Lin, LI Hongbiao, GAO Dengke   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Advanced Steering Control Algorithm for Semi-Trailer Trucks Considering Trailer Dynamics and Lateral Motion Delay

IEEE Access
In this paper, a novel steering control algorithm for semi-trailer trucks is proposed, which effectively incorporates the vehicle’s dynamic characteristics and compensates for lateral motion delays. To model the tractor and trailer, both kinematic
Geonyeong Park, Yoonyong Ahn, Sangwon Han   +2 more
doaj   +1 more source