Results 101 to 110 of about 15,527,786 (403)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

The state of state and local government finance [PDF]

open access: yes
This paper provides an overview of the state-local government sector, a review of the short-run impact of the 2007-09 recession on state and local governments, and a brief summary of key long-run challenges state and local governments will encounter in ...
Ronald C. Fisher
core  

How Have Health Benefits Changed in State and Local Governments from 1998 to 2011? [PDF]

open access: yes, 2012
[Excerpt] This issue of Beyond the Numbers looks at changes in health care plan participant provisions for state and local government employees in 1998 and 2011. Detailed provisions on state and local government benefits are collected periodically in the
Bureau of Labor Statistics
core   +1 more source

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Dispelling the Myths: The Truth about TABOR and Referendum C [PDF]

open access: yes, 2005
During the late 1990s, Colorado's Taxpayer's Bill of Rights was praised widely for its effectiveness in restraining the growth of government and providing tax relief for the residents of the state.
Michael New, Stephen Slivinski
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Les hommes qui voulaient être rois II. Sociologie des États privés

open access: yesCybergeo, 2012
With the advent of the Internet, the number of private States projects, also called micronations, witnessed a strong increase. Several analysts thought they were witnessing a movement calling for the refoundation of the very concept of State, of ...
Frédéric Lasserre
doaj   +1 more source

State of California Sea-Level Rise Guidance [PDF]

open access: yes, 2018
Author N/A Published by State ...
Agency, State Government
core   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

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