Results 71 to 80 of about 483,839 (260)

Folga orçamentária em uma Secretaria da Fazenda: um caso no nível do governo estadual no Brasil Holgura presupuestaria en el Departamento del Tesoro: un caso al nivel del gobierno estatal en Brasil Budgetary slack in a Treasury Department: a case in the state government level in Brazil

Revista de Administração Pública, 2013
Organizações públicas vêm adotando modelos de mensuração de desempenho (MMD), a exemplo da iniciativa privada, buscando gerar incentivos à eficiência de equipes de servidores.
Alyne Anteveli Osajima, André Carlos Busanelli de Aquino   +1 more
doaj  

Diagnostics and treatment of Clostridium difficile-associated disease: Guidelines of the Russian gastroenterological association

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of publication. To present with clinical guidelines of the Russian gastroenterological association on Clostridium difficile-associated disease management to practical doctors. Summary. Clostridium difficile-associated disease develops at disorders of
V. T. Ivashkin, N. D. Yushchuk, I. V. Mayev, Tatyana L Lapina, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, A. S. Trukhmanov, A. A. Sheptulin, Ye. K. Baranskaya, O. S. Lyashenko, K. V. Ivashkin   +11 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The role of polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
Aim of investigation. To estimate the role of genetic polymorphism (rs1800566) of NAD(F)H quinone oxidoreductase-1 in development of acute pancreatitis in the Russian population. Material and methods.
T. A. Samgina, Y. V. Kanishchev, S. N. Grigor’Yev, P. M. Nazarenko, A. V. Polonikov   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Local Government Debt Report June 30, 2015 [PDF]

, 2014
The South Carolina Office of the State Treasurer annually publishes reports on the annual state debt and local government debt. The local debt report provides information on the outstanding debt obligations of all local governments, as submitted to the ...
South Carolina Office of the State Treasurer
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Diagnostics and treatment of peptic ulcer: clinical guidelines of the Russian gastroenterological Association

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018
The aim of publication. To present modern concept on etiology and pathogenesis of the peptic ulcer (PUD) to general practitioners, to acquaint them with modern diagnostic methods and main treatment approaches of this disease. Summary.
V. T. Ivashkin, A. A. Sheptulin, I. V. Mayev, Ye. K. Baranskaya, A. S. Trukhmanov, T. L. Lapina, S. G. Burkov, A. V. Kalinin, A. V. Tkachev   +8 more
doaj   +1 more source

Local Government Debt Report June 30, 2013 [PDF]

, 2013
The South Carolina Office of the State Treasurer annually publishes reports on the annual state debt and local government debt. The local debt report provides information on the outstanding debt obligations of all local governments, as submitted to the ...
South Carolina Office of the State Treasurer
core