Results 91 to 100 of about 17,765,664 (260)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Treatment of an Opposing Metabolic Situation: GLUT1‐Deficiency Syndrome and Type 1 Diabetes
JIMD ReportsGlucose transporter type 1 deficiency syndrome (GLUT1‐DS) is a rare inborn disorder of metabolism leading to encephalopathy due to disturbed glucose transport via the blood–brain‐barrier and consecutive energy deficit of the brain.
Anna K. Schoenlaub +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Report and recommendations of the Special Advisory Committee for the State Mental Hospitals. [1948]
, 1948 "Submitted to Governor Frank Carlson." "December 29, 1948." Includes bibliographical references (i.e. Exhibits)."Pursuant to your request of September, 1948, to undertake an investigation of the conditions in the mental hospitals of the State of Kansas ...
Kansas. Special Advisory Committee for the State Mental Hospitals.
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Nigerian Frontline Medicine JournalBackground: Cardiovascular diseases have remained major causes of death globally. Early identification of individuals at risk of cardiovascular disease and appropriate intervention is needed in order to reduce the disease burden.
Adeyinka O. Ilesanmi +5 more
doaj
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Frontiers in Public HealthObjectiveEpidemics are sudden and rapidly spreading. Hospitals in underdeveloped areas are particularly vulnerable in case of an outbreak. This paper aims to assess the epidemic risk state and its change trend of hospitals in different epidemic stages ...
Ming Yang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Journal of Community Hospital Internal Medicine Perspectives, 2019 Background: Chronic non-cancer pain is a common cause of primary care physicians’ office visits. Objective: To determine the impact of adopting screening and monitoring measures in primary care settings on the illicit substance use behavior of patients ...
Abdelrahman Ahmed +2 more
doaj +1 more source