Results 41 to 50 of about 691,640 (219)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Intelligent Assessment Framework of Unmanned Air Vehicle Health Status Based on Bayesian Stacking

Batteries
This paper proposed a stacking-based ensemble model to replace the traditional single machine learning model prediction approach, significantly improving the evaluation efficiency of SoC and SoH of lithium batteries.
Junfu Qiao, Jinqin Guo, Yu Zhang, Yongwei Li   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Robust Online Estimation of State of Health for Lithium-Ion Batteries Based on Capacities under Dynamical Operation Conditions

Batteries
Lithium-ion batteries, as the main energy storage component of electric vehicles (EVs), play a crucial role in ensuring the safe and reliable operation of the battery systems through monitoring their state of health (SOH). However, temperature variations
Xiaoxuan Wu, Jian Chen, Hu Tang, Ke Xu, Mingding Shao, Yu Long   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

EFFECTS OF DIFFERENT N:K RATIOS AND NPK LEVELS ON SWEET POTATO

Annals of Tropical Research, 1986
Generally, plants that received NPK fertilizer had better stand than those that did not receive either N or K. However, nitrogen had greater influence than potassium on the vegetative growth of the plant, Root formation and yield were significantly ...
Letecia Q. Sarong, Bernardita F. Quirol, Marianito R. Villanueva   +2 more
doaj  

Entropy profile of NCR 18650 cylindrical cell at various states of health

Heliyon
Entropy measurement at various states of charge (SOC) is a potential non-destructive tool for characterizing lithium-ion batteries; however, traditional potentiometric methods are time-consuming. To address this, we developed a fast potentiometric method
Yerkin Serik, Desmond Adair, Zhumabay Bakenov, Berik Uzakbaiuly   +3 more
doaj   +1 more source