Results 51 to 60 of about 655,217 (269)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Novel Test Procedure for Assessing Lead–Acid Batteries for Partial-State-of-Charge Duty Using Internal Resistance Charge Acceptance Technique

Batteries
Battery energy storage systems (BESSs) are often used in partial-state-of-charge (PSOC) operation due to the desire for flexibility of charge and discharge. Lead–acid batteries are a good candidate to be used in battery energy storage due to their safety,
Max Parker, Richard McMahon
doaj   +1 more source

Battery Management Systems in Electric and Hybrid Vehicles

Energies, 2011
The battery management system (BMS) is a critical component of electric and hybrid electric vehicles. The purpose of the BMS is to guarantee safe and reliable battery operation.
Michael Pecht, Kwok L. Tsui, Yinjiao Xing, Eden W. M. Ma   +3 more
doaj   +1 more source

ON STATES, ON A LATTICE, WITH HALF-INTEGRAL CHARGE [PDF]

Nuclear Physics B, 1983
In certain molecular models, and related one-dimensional field theories, localized objects appear with half-integral expectation values of charge. We consider whether these states are eigenstates of charge, with half-integral eigenvalue. We find that it is indeed so for a suitably diffuse definition of the charge operator in question.
Bell, JS, Rajaraman, R
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

East Meets West: A Whole-Person Approach in Integrated Care

International Journal of Integrated Care
Introduction: Whole-person approach represents a fundamental tenet of integrated care globally. However, there remains a lack of consensus regarding its precise definition and an inclination towards superficial and formal implementation.
Minmin Luo, Kexing Liu, Shanshan Hong
doaj   +1 more source

A universal state-of-charge algorithm for batteries [PDF]

Proceedings of the 47th Design Automation Conference, 2010
State-of-charge (SOC) measures energy left in a battery, and it is critical for modeling and managing batteries. Developing efficient yet accurate SOC algorithms remains a challenging task. Most existing work uses regression based on a time-variant circuit model, which may be hard to converge and often does not apply to different types of batteries ...
Bingjun Xiao, Yiyu Shi 0001, Lei He 0001
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source