Results 91 to 100 of about 169,909,800 (296)

Totul e atât de firesc în tăcerea noastră. Sau despre infracțiunea de omisiunea declarării unor informații [PDF]

Forum Juridic, 2020
Following the state of emergency declared as a result of the COVID19 pandemic, the Romanian legislator adopted in March 2020 an Emergency Ordinance which, among others, modified the Criminal Code and introduced a new offence, which sanctions the omission
Andra-Roxana Trandafir
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pandemia, ponderação entre direitos e paradigmas da emergência

Revista Brasileira de Direito
O estado de emergência pandêmica exige do intérprete a identificação de coordenadas para um equilíbrio adequado entre os direitos do indivíduo e os direitos da coletividade como um todo.
Federico Losurdo
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Executive Migration Governance and Law-making in the European Union: Towards a State of Exception

European Papers
(Series Information) European Papers - A Journal on Law and Integration, 2024 9(2), 513-527 | Article | (Table of Contents) I. Introduction. – II. The rise of executive migration governance in the EU. – III. Emergency: when soft law creates law.
Aida Halilovic
doaj   +1 more source

The Current State of the Pediatric Emergency Medicine Workforce and Innovations to Improve Pediatric Care

, 2018
Many hospitals and emergency departments lack resources to optimally care for ill and injured children, perpetuating risks of receiving fragmented and “uneven” care.
Marcin, James P., Faris, Gregory W., Weinstein, Elizabeth   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Bosnia and Herzegovina during the First World War [PDF]

Crimen (Beograd), 2018
Bosnia and Herzegovina has entered in The First World War as the part od Austro Hungary. Their citizens were mobilized and sent to the fronts in Serbia, Russia and Italy due to participate in the war.
Milojević Momir
doaj  

Impactul stării de urgență asupra fenomenului criminal - Certitudine și probabilitate [PDF]

Forum Juridic, 2020
The essay addresses some aspects regarding the characteristics of the criminal phenomenon and the state reaction against it, in the context of the state of emergency established following the beginning of the coronavirus pandemic (SARS CoV-2).
Valerian Cioclei
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source