Results 101 to 110 of about 3,090,729 (363)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

O genocídio da população negra no Brasil contemporâneo e seu agravamento a partir da intervenção federal militar no estado do Rio de Janeiro

open access: yesConfluenze, 2018
Based on the articulation between the idea of an enemy in criminal law and the analysis of the historical importance of racism in the structure of our society, we will analyse how we are facing a real genocide of the black population in Brazil today ...
Mariana Paganote Dornellas   +1 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Homo Sacer in Beckett’s Waiting for Godot

open access: yesCrossings
Agamben’s concept of homo sacer may have Roman genesis but its modern and postmodern connotation is far more consequential. Since the present world is a cauldron of biopolitical activities, its effect on the general populace, especially after the Second
Md. Nurul Quayum, Masrufa Alam
doaj   +1 more source

UK State Pension Reform in a Public Choice Framework [PDF]

open access: yes, 2010
Social security systems for old age have been explicitly studied in a public choice framework for over 30 years. They illustrate extremely well the problems of allocating economic resources through a system of voting.
Booth, P. M.
core  

Breaking a monad-comonad symmetry between computational effects

open access: yes, 2014
Computational effects may often be interpreted in the Kleisli category of a monad or in the coKleisli category of a comonad. The duality between monads and comonads corresponds, in general, to a symmetry between construction and observation, for instance
Dumas, Jean-Guillaume   +2 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Racial quotas in university vis-à-vis the state of exception

open access: yesRevista Latinoamericana de Bioética, 2016
There is a close interconnection between Education and Bioethics, as explicitly stated by the Universal Declaration of Bioethics and Human Rights and by the Universal Declaration of Human Rights.
Dario Palhares   +2 more
doaj   +1 more source

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