Results 121 to 130 of about 177,535,925 (299)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Papua Under The State of Exception
, 2020 The paper argues that in post-Suharto's Indonesia, Papua remains under Carl Schmitt's state of exception in which law is suspended to allow executive power of the state to reign with little restrictions.
Budi Hernawan; Driyarkara School of Philosophy, Jakarta
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The European Union, state of exception and state transformation - Romania, Turkey and ethnic minority politics [PDF]
, 2011 The dissertation argues that the modern national sovereignty is the political expression of modern subjectivity and it dominates as such the contemporary discourse of human life, ethnic minorities included, in world politics.
Mateescu, D
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The State of Exception and Exceptional States in Elizabeth Bowen’s Wartime Ghost Stories
Open Library of Humanities, 2019 In this article, I consider Elizabeth Bowen’s depiction of the impact on citizens of their changing political and legal relationship to the British state during World War II, using Agamben and Freud’s writing about wartime behaviour of the state to illuminate Bowen’s short fiction, in particular ‘The Demon Lover’ and ‘Green Holly.’ Although from ...
openaire +3 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Governor Corzine's State of the State
, 2009 Governor Corzine discusses the economy and his administration's efforts, the coming year, education and public safety, and budget reductions in the current and upcoming budget in his State of the State ...
Office of the Governor, Corzine, Jon
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source