Results 101 to 110 of about 177,535,925 (299)

Exceptional Bound States in the Continuum

Physical Review Letters
Bound states in the continuum and exceptional points are unique singularities of non-Hermitian systems. In optical implementations, the former demonstrate strong enhancement of the electromagnetic field, while the latter exhibit high sensitivity to small perturbations. Hence, exceptional points are being actively investigated as next-generation optical
Adrià Canós Valero, Zoltan Sztranyovszky, Egor A. Muljarov, Andrey Bogdanov, Thomas Weiss   +4 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dynamics of Extreme Violence during the Indonesian National Revolution in Subang, 1945-1949

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
This research aims to reconstruct the patterns and impacts of violence that occurred in the Subang region, particularly in the Pamanoekan and Tjiasem lands (P & T Lands), during the early period of the Indonesian War of Independence.
Aji Samsudin, Ibnu Sodiq
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Utah State Officers (1896) P.3

, 1897
Officials who won out in the election of Nov., 1896. All are Utah State officials with the exception of Senator Rawlins (center) who was elected to the United States ...

core  

When the exception is the rule : rationalising the 'medical exception' in Scots law [PDF]

, 2020
No physician who performs a legitimate medical operation on a patient commits a criminal offence or a delict. This is so in spite of the fact that to infringe the bodily integrity of another person is plainly both a crime and a civil wrong ...
Brown, Jonathan
core  

State of "Emergency" for health but State of "Exception" for people: Guinea-Bissau's paradox in the battle against Covid-19. [PDF]

City Soc (Wash), 2020
de Barros M, Casimiro A, Cassamá AS, Mané C, Jau F, Jorge Semedo R.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Homo Sacer in Beckett’s Waiting for Godot

Crossings
Agamben’s concept of homo sacer may have Roman genesis but its modern and postmodern connotation is far more consequential. Since the present world is a cauldron of biopolitical activities, its effect on the general populace, especially after the Second
Md. Nurul Quayum, Masrufa Alam
doaj   +1 more source