Results 111 to 120 of about 177,535,925 (299)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Exception, sovereignty and constitutional order: A Schmittian reading of Turkey’s constitutional trajectory

open access: yesGlobal Constitutionalism
This article examines Turkey’s constitutional trajectory through Carl Schmitt’s concepts of sovereignty, exception and dictatorship. It argues that Turkey’s political development cannot be fully understood as a process of gradual democratic erosion alone
Özgür Salmanoğ
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

State of Ohio - agency libraries

open access: yes
In alphabetical order with option to restrict results by county; also includes index to branch library.; Designed by AVV, Inc.; Updated on an ongoing basis.; Also available in pdf and Excel versions, updated quarterly, for download/print use ...
State Library of Ohio.
core  

The limits to good governance and the state of exception: a case study of North Sea fisheries

open access: yes, 2010
This paper explores a series of maxims, widely known in policy and academic circles as the ‘principles of good governance’, which state that policymaking in the European Union (EU) should be participatory, conducted as close to citizens as practicable ...
Griffin, L., Liza Griffin
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

State of emergency, state of exception : a critical investigation [PDF]

open access: yes, 2011
Dissertation (LLM)--University of Pretoria, 2011.In fact, the exercise of emergency powers is a phenomenon common to both democratic and undemocratic governments, the only difference between the two being the presence or absence of check and balances to ...

core  

La emergencia una (nueva) logica de seguridad politica.

open access: yesColombia Internacional, 2005
This article explores a series of recent theoretical contributions on the topic of security. Currently, the implementation of practices, processes and political rationalities that aim to administer, regulate and decide over human life, prove to be a ...
Juan Felipe Moreno.
doaj  

De l’exception-comme-règle au véritable état d’exception. Walter Benjamin, penseur contemporain de l’exception

open access: yesTr@jectoires
Walter Benjamin’s research led him to reflect on the state of exception, even if his uses of the concept remain little known. Beginning with Ursprung des deutschen Trauerspiels, in which he drew on classical theories of exception, Benjamin's position ...
Anna Migliorini
doaj   +1 more source

Home - About - Disclaimer - Privacy