Results 121 to 130 of about 3,090,729 (363)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Giorgio Agamben: on health scare and the religion of science

Inscriptions, 2020
Around the time of the Covid-19 pandemic Italian philosopher Giorgio Agamben published a series of incisive, short texts on the conjuncture of biopolitics and the governmentality of the global health scare.
Giorgio Agamben, Adam Kotsko, Inscriptions Editorial Team   +2 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Contribuições da Filosofia de Giorgio Agamben à Leitura do Caso Justransicional Colombiano

Araucaria, 2018
The present research problematizes the conception of state of exception proposed by Giorgio Agamben and its perpetuation in the present democracies, from the reading of the conflict existing in Colombia. In order to do so, the objective was to understand
Fernando Cardoso, Jessyca Iasmim de Souza   +1 more
doaj  

POLITICAL-THEOLOGICAL SOURCE OF THE “STATE OF EXCEPTION”: RE-READING SOVEREIGNTY WITHIN THE DIVINE OIKONOMIA

, 2020
Baştürk Baştürk
openalex   +1 more source

Egypt’s unbreakable curse: Tracing the State of Exception from Mubarak to Al Sisi [PDF]

, 2019
Lucia Ardovini, Simon Mabon
openalex   +1 more source

A kepstrum approach to filtering, smoothing and prediction [PDF]

, 2002
The kepstrum (or complex cepstrum) method is revisited and applied to the problem of spectral factorization where the spectrum is directly estimated from observations.
Barrett, J.F., Moir, T.J.
core  

On Scale Versus Conformal Symmetry in Turbulence

, 2018
We consider the statistical description of steady state fully developed incompressible fluid turbulence at the inertial range of scales in any number of spatial dimensions.
Oz, Yaron
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source