Results 131 to 140 of about 4,138,957 (310)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Evaluation of drought-tolerant varieties based on root system architecture in cotton (Gossypium hirsutum L.)

open access: yesBMC Plant Biology
Background Root system architecture (RSA) exhibits significant genetic variability and is closely associated with drought tolerance. However, the evaluation of drought-tolerant cotton cultivars based on RSA in the field conditions is still underexplored.
Congcong Guo   +11 more
doaj   +1 more source

Multispectral and Chlorophyll Fluorescence Imaging Fusion Using 2D-CNN and Transfer Learning for Cross-Cultivar Early Detection of Verticillium Wilt in Eggplants

open access: yesAgronomy
Verticillium wilt is characterized by chlorosis in leaves and is a devastating disease in eggplant. Early diagnosis, prior to the manifestation of symptoms, enables targeted management of the disease.
Dongfang Zhang   +6 more
doaj   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

Checking Up on Retail-Based Health Clinics: Is the Boom Ending? [PDF]

open access: yes, 2008
Outlines trends in the growth of retail-based clinics providing basic care at pharmacies and other retail settings. Examines who uses them, where, for what services, and why; insurance coverage and reimbursement rates; and variations in state ...
Genna R. Cohen, Ha T. Tu
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Fiscal regulation and expenditure pattern in Maharashtra state [PDF]

open access: yes
The Fiscal Responsibility and Budgetary Management Act of 2004 has improved state finances of Maharashtra, India. It has also reduced fiscal deficit for state.
Rode, Sanjay
core   +1 more source

CAM regulation in the United States

open access: yesComplementary Therapies in Medicine, 2002
As complementary and alternative medical (CAM) therapies increasingly penetrate conventional health care, physicians and other health care providers find themselves providing (or being asked to provide) care at the borderland of medicine, ethics, public policy and law. Whereas historically, many physicians and patients shunned a dialogue concerning use
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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