Results 41 to 50 of about 4,138,957 (310)

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

A 90-day safety study of meat from MSTN gene-edited Mongolian cattle in mice

Scientific Reports
The knockout (KO) of the myostatin (MSTN) gene can increase muscle production in Mongolian cattle; however, the safety of MSTN-KO beef has not been evaluated.
Jia-Hao Chen, Hong-Yu Gong, Zhao-Yu Wen, De-Zheng Wang, Tao Wang, Li-Shuang Song, Xue-Fei Liu, Guang-Peng Li, Chun-Ling Bai, Lei Yang   +9 more
doaj   +1 more source

RhizoPot platform: A high-throughput in situ root phenotyping platform with integrated hardware and software

Frontiers in Plant Science, 2022
Quantitative analysis of root development is becoming a preferred option in assessing the function of hidden underground roots, especially in studying resistance to abiotic stresses.
Hongjuan Zhao, Nan Wang, Nan Wang, Hongchun Sun, Lingxiao Zhu, Ke Zhang, Yongjiang Zhang, Jijie Zhu, Anchang Li, Zhiying Bai, Xiaoqing Liu, Hezhong Dong, Liantao Liu, Cundong Li   +13 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

MSTN gene editing does not alter reproductive capacity but modifies gestational metabolism in Mongolian cattle

BMC Veterinary Research
Background The extended sexual maturity and prolonged gestation period of cattle limit their economic viability and hinder the breeding of superior genotypes.
Xiaoyu Zhao, Jia Liu, Jiechuan Xiao, Yuan Yun, Chunjie Bo, Yuxin Gao, Lishuang Song, Chunling Bai, Zhuying Wei, Li Zhang, Lei Yang, Guangpeng Li, Guanghua Su   +12 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Quantifying Dynamic Regulation in Metabolic Pathways with Nonparametric Flux Inference [PDF]

, 2019
One of the central tasks in systems biology is to understand how cells regulate their metabolism. Hierarchical regulation analysis is a powerful tool to study this regulation at the metabolic, gene-expression, and signaling levels.
He, Fei, Stumpf, Michael P H
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Comparative analysis of reproductive organs, hormones and blood metabolism of MSTN mutated and non-mutated cows during gestation

BMC Veterinary Research
Background Long breeding cycle, long calving intervals and typical single calves limit the potential for improving their economic benefits. Ensuring the reproductive performance and efficiency of cows are crucial to increasing their economic value ...
Xiaoyu Zhao, Jiechuan Xiao, Yuan Yun, Chunjie Bo, Yuxin Gao, Lishuang Song, Chunling Bai, Zhuying Wei, Li Zhang, Lei Yang, Guanghua Su, Guangpeng Li   +11 more
doaj   +1 more source

Single- and Multi-Locus GWAS Unravels Novel Genomic Regions Related to Low-Phosphate Stress in Cotton Seedlings

Plants
Phosphorus (P) is an essential nutrient for plant growth, and low-phosphorus (LP) stress significantly limits cotton productivity. Here, we conducted single- and multi-locus genome-wide association studies (GWASs) on four LP-related traits using 419 ...
Xianxu Wei, Siyu Yao, Jiangnuo Di, Jiaxin Guan, Aohan Wang, Jie Yang, Luyao Zhang, Yang Liu, Mengyao Liang, Zhihao Niu, Xuan Zhang, Jiarui Xue, Mengxue Shen, Lin Li, Yao Su, Zhengwen Sun   +15 more
doaj   +1 more source