Results 61 to 70 of about 1,394,346 (266)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Analysis and prediction of LUCC change in Huang-Huai-Hai river basin

Open Geosciences, 2020
Land use/cover change plays an important role in human development and environmental health and stability. Markov chain and a future land use simulation model were used to predict future change and simulate the spatial distribution of land use in the ...
Wang Jianwei, Wang Kun, Qin Tianling, Nie Hanjiang, Lv Zhenyu, Liu Fang, Shi Xiaoqing, Hu Yong   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Integrated metabolite profiling and transcriptomic analysis reveal mechanisms underlying quinoa inflorescence color

BMC Plant Biology
Background Quinoa exhibits striking inflorescence color variation, with red inflorescences (RF) characterized by higher anthocyanin accumulation than green inflorescences (GF).
Jialin Li, Shance Niu, Jiaxing Wei, Chang Liu, Zhifei Tang, Lumeng Zheng, Guojun Mu, Wei Lv, Xinbo Sun   +8 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

State Regulation of Radioactive Materials [PDF]

Public Health Reports (1896-1970), 1964
W ITH minor exceptions, the genesis of interest by States in controlling radioactive materials stemmed from the enactment of Public Law 86-373 by Congress in 1959. This added section 274 to the Atomic Energy Act, providing for transfer from the U.S. Atomic Energy Commission to States of regulatory responsibility and authority over byproduct and source ...
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Engineering a CRISPR-associated IscB system for developing miniature genome-editing tools in human cells and mouse embryos

Nature Communications
IscB, as the putative ancestor of Cas9, possesses a compact size, making it suitable for in vivo delivery. OgeuIscB is the first IscB protein known to function in eukaryotic cells but requires a complex TAM (NWRRNA).
Fei Zhang, Yuxin Peng, Dongdong Fan, Guoxu Song, Xing Gao, Yong Tian   +5 more
doaj   +1 more source

Comprehensive Analysis of Phenotypic Traits in Chinese Cabbage Using 3D Point Cloud Technology

Agronomy
Studies on the phenotypic traits and their associations in Chinese cabbage lack precise and objective digital evaluation metrics. Traditional assessment methods often rely on subjective evaluations and experience, compromising accuracy and reliability ...
Chongchong Yang, Lei Sun, Jun Zhang, Xiaofei Fan, Dongfang Zhang, Tianyi Ren, Minggeng Liu, Zhiming Zhang, Wei Ma   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source