Results 101 to 110 of about 481,418 (265)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

RESULTS OF RECONSTRUCTION OF IRON FOUNDRY OF GOMEL CAR REPAIR PLANT NAMED AFTER M, I. KALININ

Литьë и металлургия, 2009
The materials reflecting technical and economic aspects of reconstruction of the iron foundry, specializing on mass production of brake blocks for mobile rail transportation, are presented.
Z. F. Figlin, I. V. Odarchenko, S. L. Rovin   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

GPT2-mediated Glutamate to α-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis

JACC: Basic to Translational Science
Summary: Cardiac fibroblasts play a key role in heart fibrosis, but how their metabolism changes during this process is unclear. This study shows that mesenchymal stem cell–derived extracellular vesicles reduce fibrosis in mice after heart pressure ...
Yongjian Chen, PhD, Fei Liao, PhD, Jingyi Wang, PhD, Jing Zhao, MSc, Yinghui Xu, PhD, Qiming Chen, MSc, Tingting Hong, MSc, Kaiqi Lv, PhD, Qingju Li, MD, PhD, Xiaoying Chen, PhD, Changchen Xiao, MD, PhD, Lingjun Wang, PhD, Guohua Li, PhD, Changle Ke, PhD, Jiayue Cai, MM, Jiamin Li, PhD, Shuyuan Sheng, PhD, Jiacheng Wang, PhD, Xianpeng Wu, PhD, Yating Ruan, MM, Feimu Zhang, MM, Rongrong Wu, PhD, Yinchuan Xu, MD, PhD, Wei Zhu, PhD, Yang Xu, PhD, Jian’an Wang, MD, PhD, Cheng Ni, MD, PhD, Xinyang Hu, PhD   +27 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence

Acta Neuropathologica Communications
TDP-43 mislocalization and aggregation are key pathological features of amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD). However, existing transgenic hTDP-43 WT or ∆NLS-overexpression animal models primarily focus on late-stage TDP-
Joy Mitra, Manohar Kodavati, Prakash Dharmalingam, Erika N. Guerrero, K. S. Rao, Ralph M. Garruto, Muralidhar L. Hegde   +6 more
doaj   +1 more source

Automated three-dimensional left atrial analysis on computed tomography angiography: reproducibility and workflow efficiency of eight clinically relevant metrics using a deep learning pipeline

Frontiers in Bioengineering and Biotechnology
BackgroundAccurate and reproducible quantification of LA anatomy from CTA is essential for ablation, LAAC, and structural interventions, yet manual measurements are time-consuming and prone to inter-observer variability.ObjectivesTo validate a deep ...
Youqi Fan, Youqi Fan, Youqi Fan, Jian Ye, Jian Ye, Jian Ye, Xiaoya Wang, Xiaoya Wang, Xiaoya Wang, Liuguang Song, Liuguang Song, Liuguang Song, Yaping Wang, Yaping Wang, Yaping Wang   +14 more
doaj   +1 more source