Results 111 to 120 of about 481,418 (265)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Availability of multi-state repairable systems

Journal of Physics: Conference Series
Abstract The aim of the paper is to determine the asymptotic availability (and unavailability) of the system on a model example. Kolmogorov differential equations were used to determine them. Availability is understood as the ability of the system to be in a state capable of performing the required functions under given conditions, at
E Labašová, V Labaš
openaire   +1 more source

Aortic Valve Repair: State of the Art

Journal of the Heart Valve Society
Aortic valve repair has now been shown by long-term evidence to reduce valve-related mortality while restoring quality and life expectancy similar to the general population. However the rate of repair worldwide remains low (around 15%-20%), while 80% of regurgitant valves can be repaired.
Emmanuel Lansac, Pouya Youssefi
openaire   +1 more source

Biomechanical Comparison Between Double-Row Repair and Soft Tissue Tenodesis for Treatment of Proximal Rectus Femoris Avulsions

Orthopaedic Journal of Sports Medicine
Background: Some patients with proximal rectus femoris (PRF) avulsions require surgical treatment after failed nonoperative treatment. There is no consensus on the superiority of suture anchor repair with the suture-bridge repair (SBR) technique versus ...
Haruki Nishimura MD, PhD, Kohei Yamaura MD, PhD, Vera M. Stetzelberger MD, Alexander R. Garcia BS, Justin R. Brown MD, Justin F.M. Hollenbeck MS, Mitchell S. Mologne BS, Soshi Uchida MD, PhD, Marc J. Philippon MD   +8 more
doaj   +1 more source

Ethanol infusion of the vein of Marshall reduces localized voltage but preserves mitral isthmus conduction velocity

Frontiers in Cardiovascular Medicine
BackgroundEthanol infusion of the vein of Marshall (EIVOM) has emerged as a promising adjunct to pulmonary vein isolation (PVI) for atrial fibrillation (AF).MethodsPatients undergoing catheter ablation for persistent AF (>3 months) were enrolled in ...
Yi Lu, Yi Lu, Yi Lu, Li Shu, Li Shu, Li Shu, Chunhui Liu, Chunhui Liu, Chunhui Liu, Shenghui Ma, Shenghui Ma, Shenghui Ma, Zhejun Cai, Zhejun Cai, Zhejun Cai   +14 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Existing State of Repair Materials

Concrete Journal, 1995
Matsusato, H., Okamoto, T., Kubokawa, T.
openaire   +3 more sources