Results 131 to 140 of about 3,307,050 (303)
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Prioritizing Professional Responsibility and the Legal Profession: A Preview of the United States Supreme Court’s 2009–2010 Term [PDF]
, 2009 This term, the Supreme Court is scheduled to hear ten cases on the role of attorneys and the practice of law. In doing so, the Court is departing from its normal practice of hearing two, or at most three, cases on professional responsibility. Prof. Renee
Knake, Renee Newman
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The efficient allocation and usage of resources in the higher education system [PDF]
The performance orientation of the higher education system, along with its evaluation and financing according to quality criteria may remain unfulfilled objectives if there will not be the desire and determination to promote and apply such policies ...
Rodica GHERGHINA, Tatiana MOSTEANU
core
Rethinking the State-Local Relationship: Local Economic Development [PDF]
, 2011 Examines issues involved in shifting responsibility for redevelopment and enterprise zones from the state to localities, including relaxing local funding constraints to give localities more authority and incentives to support the most effective ...
Jed Kolko
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The analysis of the customers’ perception on CSR – tridimensional approach – cultural, economical and social [PDF]
There has been observed a more obvious need of the companies to appeal to community in order to find the necessary support and resources to accomplish their mission and objectives.
Adrian MICU +3 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
CORPORATIVE SOCIAL RESPONSIBILITY, PARTNER OR OPPONENT OF KNOWLEDGE MANAGEMENT? [PDF]
It appeared as an initiative of the big transnational companies in their fight for the maintaining and the improvement of their competitive position, Corporative Social Responsibility imposes itself nowadays as an innovative concept, usually associated ...
Anca Maria HRISTEA
core
Responsibility and blame: a structural-model approach [PDF]
, 2003 Causality is typically treated an all-or-nothing concept; either A is a cause of B or it is not. We extend the definition of causality introduced by Halpern and Pearl [2001] to take into account the degree of responsibility of A for B.
Chockler, Hana, Halpern, Joseph Y.
core +3 more sources