Results 61 to 70 of about 1,023,856 (306)

The State Space Models Toolbox for MATLAB

Journal of Statistical Software, 2011
State Space Models (SSM) is a MATLAB toolbox for time series analysis by state space methods. The software features fully interactive construction and combination of models, with support for univariate and multivariate models, complex time-varying (dy ...
Jyh-Ying Peng, John A. D. Aston
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Bayesian Analysis of Unobserved Component Models Using Ox

Journal of Statistical Software, 2011
This article details a Bayesian analysis of the Nile river flow data, using a similar state space model as other articles in this volume. For this data set, Metropolis-Hastings and Gibbs sampling algorithms are implemented in the programming language Ox.
Charles S. Bos
doaj  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A self-organizing state-space-model approach for parameter estimation in Hodgkin-Huxley-type models of single neurons [PDF]

, 2012
Traditional approaches to the problem of parameter estimation in biophysical models of neurons and neural networks usually adopt a global search algorithm (for example, an evolutionary algorithm), often in combination with a local search method (such as ...
Aston, John A. D., Straub, Volko A., J. A. D. Aston (7605152), Volko A. Straub (180605), Volko A Straub, Dimitrios V Vavoulis, Jianfeng Feng (48703), John A D Aston, Volko A. Straub (7585415), Vavoulis, Dimitrios V., Feng, Jianfeng, Jianfeng Feng, J. Feng (1603219), V. A. Straub (7605149), John A. D. Aston (180611), D. V. Vavoulis (7605146), Dimitrios V. Vavoulis (180603)   +16 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Space–time proper generalized decompositions for the resolution of transient elastodynamic models [PDF]

, 2013
In this paper, we investigate ability of proper generalized decomposition (PGD) to solve transient elastodynamic models in space–time domain. Classical methods use time integration schemes and an incremental resolution process.
BOUCINHA, Lucas, AMMAR, Amine, GRAVOUIL, Anthony   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Reinforcement learning in continuous state- and action-space [PDF]

, 2014
Reinforcement learning in the continuous state-space poses the problem of the inability to store the values of all state-action pairs in a lookup table, due to both storage limitations and the inability to visit all states sufficiently often to learn the
Nichols, B.D.
core   +1 more source