Results 81 to 90 of about 2,438,026 (283)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
A lot of the defects that are present in a program are not visible to the compiler. Static code analysis is a way to find bugs and reduce the defects in a software application.
Alexandru G. Bardas
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A DSL for Resource Checking Using Finite State Automaton-Driven Symbolic Execution
Open Computer Science, 2020 Static analysis is an essential way to find code smells and bugs. It checks the source code without execution and no test cases are required, therefore its cost is lower than testing.
Fülöp Endre, Pataki Norbert
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
工程科学与技术Objective The hinge joint connection in traditional prefabricated beam transverse connections exhibits weak strength and poor stiffness, whereas the wet joint connection involves complex construction processes and lengthy durations.
Lin WANG +6 more
doaj
Stacy-static code analysis for enhanced vulnerability detection
Cogent Engineering, 2017 Computer program analysis refers to the automatic analysis of the behavior of a user defined program. An application of program analysis is to determine the quality of source code.
Pankaj Lathar +2 more
doaj +1 more source
Modeling and Propagation of Noisy Waveforms in Static Timing Analysis
, 2005 A technique based on the sensitivity of the output to input waveform is presented for accurate propagation of delay information through a gate for the purpose of static timing analysis (STA) in the presence of noise.
Ajami, Amir H. +4 more
core +2 more sources