Results 131 to 140 of about 242,752 (310)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Using Counts as Heuristics for the Analysis of Static Models
, 1998 The upstream activities of software development are often viewed as both the most important, in terms of cost, and the yet the least understood, and most problematic, particularly in terms of satisfying customer requirements.
Phalp, Keith T. +3 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Static voltage collapse assessment for bulk power system network (SVCA) : article / Sunarny Othman [PDF]
, 2007 This paper presents the static voltage collapse assessment for bulk power system network. The study involves computation of line stability factor termed as LQP to indicate the voltage stability in a Power System.
Othman, Sunarny
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, 2011 The human face is important for social communication and in attractiveness judgements. Previous studies indicate that several facial traits may be related to mental and physical health and there is some evidence that individuals are able to judge past ...
Dennington, Lillias +11 more
core +1 more source
A Review of Airport Security and Resilience Analysis: Integration of Risk Modelling Frameworks
Applied SciencesAirports, as Critical National Infrastructure (CNI), operate as tightly coupled socio-technical systems exposed to multifaceted threats, including cyber, physical, social, environmental, and Chemical, Biological and Radiological (CBR) threats. This study
Lintong Li +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
, 2017 Traditional Deterministic Safety Assessment (DSA) and Probabilistic Safety Assessment (PSA) of complex systems have been recently challenged by the excessive conservatism of DSA and the demanding treatment of uncertainties of PSA.
Zio E., Di Maio F., Picoco C.
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